node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0638 | MMP1395 | MMP0638 | MMP1395 | Conserved hypothetical protein. | Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. | 0.932 |
MMP0638 | mre11 | MMP0638 | MMP1340 | Conserved hypothetical protein. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.762 |
MMP0638 | pcnA | MMP0638 | MMP1711 | Conserved hypothetical protein. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.938 |
MMP0638 | radA | MMP0638 | MMP1222 | Conserved hypothetical protein. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.932 |
MMP0638 | radB | MMP0638 | MMP0617 | Conserved hypothetical protein. | DNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.932 |
MMP0638 | rfcA | MMP0638 | MMP0427 | Conserved hypothetical protein. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.743 |
MMP0638 | rfcB | MMP0638 | MMP0322 | Conserved hypothetical protein. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.758 |
MMP0638 | rpa | MMP0638 | MMP1032 | Conserved hypothetical protein. | Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91. | 0.960 |
MMP0638 | topA | MMP0638 | MMP0956 | Conserved hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.979 |
MMP1024 | mre11 | MMP1024 | MMP1340 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | DNA repair exonuclease of the SbcD/Mre11-family; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.423 |
MMP1024 | pcnA | MMP1024 | MMP1711 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.825 |
MMP1024 | radA | MMP1024 | MMP1222 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.521 |
MMP1024 | radB | MMP1024 | MMP0617 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | DNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.425 |
MMP1024 | rfcA | MMP1024 | MMP0427 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.867 |
MMP1024 | rfcB | MMP1024 | MMP0322 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | Replication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. | 0.883 |
MMP1024 | rpa | MMP1024 | MMP1032 | MCM family related protein; Citation: Nucleic Acids Res. 1992;20(21):5571-7. Molec. Microbiol. 1998; 29: 955-961. J. Biol. Chem. (2000) 275: 15049-15059; Belongs to the MCM family. | Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91. | 0.945 |
MMP1395 | MMP0638 | MMP1395 | MMP0638 | Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. | Conserved hypothetical protein. | 0.932 |
MMP1395 | pcnA | MMP1395 | MMP1711 | Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. | Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.895 |
MMP1395 | radA | MMP1395 | MMP1222 | Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. | DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.828 |
MMP1395 | radB | MMP1395 | MMP0617 | Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain. | DNA repair and recombination protein radB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity). | 0.828 |