tmk protein (Methanococcus maripaludis S2) - STRING interaction network

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Score

tmk

Thymidylate kinase. (199 aa)

Predicted Functional Partners:

dcd

0.972

thyA-2

0.962

ndk

0.958

surE

0.940

dut

0.934

pyrH

0.821

MMP1033

0.737

MMP1606

0.736

rplA

0.723

cofG

0.712

Your Current Organism:

Methanococcus maripaludis S2

NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMP1033	tmk	MMP1033	MMP1034	Hypothetical protein.	Thymidylate kinase.	0.737
MMP1606	tmk	MMP1606	MMP1034	Flavoprotein:DNA/pantothenate metabolism flavoprotein.	Thymidylate kinase.	0.736
cofG	tmk	MMP0876	MMP1034	FO synthase, subunit CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.	Thymidylate kinase.	0.712
dcd	dut	MMP1426	MMP1075	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	0.908
dcd	ndk	MMP1426	MMP0283	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.930
dcd	surE	MMP1426	MMP1051	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.912
dcd	thyA-2	MMP1426	MMP1379	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.929
dcd	tmk	MMP1426	MMP1034	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	Thymidylate kinase.	0.972
dut	dcd	MMP1075	MMP1426	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	0.908
dut	ndk	MMP1075	MMP0283	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.930
dut	surE	MMP1075	MMP1051	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.919
dut	thyA-2	MMP1075	MMP1379	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.	0.929
dut	tmk	MMP1075	MMP1034	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	Thymidylate kinase.	0.934
ndk	dcd	MMP0283	MMP1426	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.	0.930
ndk	dut	MMP0283	MMP1075	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003.	0.930
ndk	pyrH	MMP0283	MMP0385	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	0.950
ndk	rplA	MMP0283	MMP0260	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release.	0.562
ndk	tmk	MMP0283	MMP1034	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Thymidylate kinase.	0.958
pyrH	ndk	MMP0385	MMP0283	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.950
pyrH	rplA	MMP0385	MMP0260	Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.	LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release.	0.757