| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMP1250 | queC | MMP1250 | MMP0226 | 6-pyruvoyl tetrahydropterin synthase. | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.998 |
| MMP1250 | queE | MMP1250 | MMP0077 | 6-pyruvoyl tetrahydropterin synthase. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.999 |
| MMP1250 | surE | MMP1250 | MMP1051 | 6-pyruvoyl tetrahydropterin synthase. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.433 |
| MMP1250 | tmk | MMP1250 | MMP1034 | 6-pyruvoyl tetrahydropterin synthase. | Thymidylate kinase. | 0.870 |
| dcd | dut | MMP1426 | MMP1075 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | 0.904 |
| dcd | ndk | MMP1426 | MMP0283 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
| dcd | rpl11 | MMP1426 | MMP1433 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.415 |
| dcd | surE | MMP1426 | MMP1051 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| dcd | thyA-2 | MMP1426 | MMP1379 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.931 |
| dcd | tmk | MMP1426 | MMP1034 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate kinase. | 0.932 |
| dut | dcd | MMP1075 | MMP1426 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.904 |
| dut | ndk | MMP1075 | MMP0283 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
| dut | surE | MMP1075 | MMP1051 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
| dut | thyA-2 | MMP1075 | MMP1379 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.931 |
| dut | tmk | MMP1075 | MMP1034 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Thymidylate kinase. | 0.934 |
| ndk | dcd | MMP0283 | MMP1426 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.930 |
| ndk | dut | MMP0283 | MMP1075 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | 0.930 |
| ndk | rpl10 | MMP0283 | MMP0259 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. | 0.640 |
| ndk | rpl11 | MMP0283 | MMP1433 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. | 0.934 |
| ndk | tmk | MMP0283 | MMP1034 | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | Thymidylate kinase. | 0.957 |