STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA2-isopropylmalate synthase; Citation: J. Bac. 176(15): 4590-6 [M. thermoautotrophicum] Porat. I. and Whitman, W.B. Unpublished deletion mutant; Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa)    
Predicted Functional Partners:
ilvE
Aminotransferase (subgroup III) similar to Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 0.990
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 
 0.974
leuC
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.973
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 
 0.970
ilvB
Acetohydroxyacid synthase large subunit; Citation: Genetics 152:1439.
  
 
 0.969
MMP1212
Unnamed protein product.
  
 
 0.950
acsA
acetyl-CoA synthetase, AMP-forming; Citation: J Bact 173:6383.
  
 
 0.937
ilvN
Acetohydroxyacid synthase small subunit.
  
 
 0.935
MMP1274
acetyl-CoA synthetase, AMP-forming-related; Citation: J Bact 173:6383.
  
 
 0.935
porB
Pyruvate oxidoreductase (synthase) subunit beta; Citation: Tersteegen, A. et al. 1997. Eur. J. Biochem. 244:862-8; Lin, WC et al, Arch Microbiol 179:444 (2003).
  
 
 0.925
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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