node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP1612 | endA | MMP1612 | MMP1132 | Conserved hypothetical protein. | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.589 |
comC | endA | MMP1133 | MMP1132 | L-sulfolactate dehydrogenase/(S)-hydroxyglutaric acid dehydrogenase; Citation: J. Bacteriol. 182:3688-3692(2000). | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.947 |
dnaG | endA | MMP1286 | MMP1132 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.927 |
dnaG | nusA | MMP1286 | MMP1366 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | KH domain:KH domain, type 1; Participates in transcription termination. Belongs to the NusA family. | 0.711 |
dnaG | pfdB | MMP1286 | MMP0245 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Prefoldin beta subunit (GimC beta subunit); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.696 |
dnaG | rpl14e | MMP1286 | MMP0625 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | KOW motif; Belongs to the eukaryotic ribosomal protein eL14 family. | 0.427 |
dnaG | spt5 | MMP1286 | MMP1434 | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.899 |
endA | MMP1612 | MMP1132 | MMP1612 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Conserved hypothetical protein. | 0.589 |
endA | comC | MMP1132 | MMP1133 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | L-sulfolactate dehydrogenase/(S)-hydroxyglutaric acid dehydrogenase; Citation: J. Bacteriol. 182:3688-3692(2000). | 0.947 |
endA | dnaG | MMP1132 | MMP1286 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.927 |
endA | hom | MMP1132 | MMP1702 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Homoserine dehydrogenase; Citation: Marchenko GN, Marchenko ND, Tsygankov YD, Chistoserdov AY. (1999)Microbiology 145:3273-82. | 0.864 |
endA | nusA | MMP1132 | MMP1366 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | KH domain:KH domain, type 1; Participates in transcription termination. Belongs to the NusA family. | 0.588 |
endA | pfdB | MMP1132 | MMP0245 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Prefoldin beta subunit (GimC beta subunit); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.593 |
endA | rnz | MMP1132 | MMP0906 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. | 0.621 |
endA | rpa | MMP1132 | MMP1032 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91. | 0.582 |
endA | rpl14e | MMP1132 | MMP0625 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | KOW motif; Belongs to the eukaryotic ribosomal protein eL14 family. | 0.563 |
endA | spt5 | MMP1132 | MMP1434 | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. | 0.598 |
hom | endA | MMP1702 | MMP1132 | Homoserine dehydrogenase; Citation: Marchenko GN, Marchenko ND, Tsygankov YD, Chistoserdov AY. (1999)Microbiology 145:3273-82. | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.864 |
nusA | dnaG | MMP1366 | MMP1286 | KH domain:KH domain, type 1; Participates in transcription termination. Belongs to the NusA family. | Possible DnaG-type primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.711 |
nusA | endA | MMP1366 | MMP1132 | KH domain:KH domain, type 1; Participates in transcription termination. Belongs to the NusA family. | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. | 0.588 |