STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemBDelta-aminolevulinic acid dehydratase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the ALAD family. (322 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82.
 
 0.997
hemL
Glutamate-1-semialdehyde aminotransferase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
 
 0.994
hemD
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.965
gtrA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.887
MMP0033
LysR family member; Contains a helix-turn-helix domain; Citation: Mol. Cell (2000) 6: 637-648. Nuc. Acids Res. (1999) 27: 4658-4670.
  
  
 0.873
cobA
uroporphyrin-III C-methyltransferase; Citation: J Bacteriol. 1991 Aug;173(15):4637-45; Belongs to the precorrin methyltransferase family.
  
  
 0.862
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
     
 0.858
cysS
Cysteinyl-tRNA synthetase.
     
 0.845
thrS
Threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family.
     
 0.828
MMP0768
Conserved Hypothetical Protein.
  
  
 0.752
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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