Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
frdAFumarate reductase/succinate dehydrogenase, flavoprotein subunit. (539 aa)    
Predicted Functional Partners:
sucC
succinate-CoA ligase (ADP-forming), beta chain.
 
 0.998
MMP1067
Uncharacterized iron-sulfur protein MMP1067; Succinate dehydrogenase/fumarate reductase iron-sulfur subunit // Methanosarcina type heterodisulfide reductase subunit D; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 
 0.997
sucD
succinate--CoA ligase (ADP-forming); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.996
fumA
Fumarate hydratase.
  
 
 0.980
MMP1548
Fe-S type hydro-lyases tartrate/fumarate beta region.
  
 
 0.980
ehbL
Ferredoxin; Citation: Tersteegen, A. and R. Hedderich. 1999. Eur. J. Biochem. 264:930-43.
  
 
 0.960
nadC
Quinolinate phosphoribosyl transferase:Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
   
 0.939
mdh
Malate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate.
 
 
 0.936
nadA
Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
   
 0.867
MMP1332
NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
 
 
 0.840
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.