node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMP0017 | MMP0059 | MMP0017 | MMP0059 | Conserved hypothetical protein. | Conserved hypothetical archaeal protein. | 0.827 |
MMP0017 | thi4 | MMP0017 | MMP1352 | Conserved hypothetical protein. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.852 |
MMP0017 | thiC | MMP0017 | MMP0187 | Conserved hypothetical protein. | Thiamine biosynthesis protein, putative; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. | 0.405 |
MMP0059 | MMP0017 | MMP0059 | MMP0017 | Conserved hypothetical archaeal protein. | Conserved hypothetical protein. | 0.827 |
MMP0059 | thi4 | MMP0059 | MMP1352 | Conserved hypothetical archaeal protein. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.827 |
MMP0415 | MMP1353 | MMP0415 | MMP1353 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Conserved hypothetical protein. | 0.430 |
MMP0415 | thi4 | MMP0415 | MMP1352 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.827 |
MMP1350 | MMP1351 | MMP1350 | MMP1351 | Conserved hypothetical protein. | N-acetyltransferase domain-containing protein; Unnamed protein product. | 0.953 |
MMP1350 | MMP1353 | MMP1350 | MMP1353 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.556 |
MMP1350 | thi4 | MMP1350 | MMP1352 | Conserved hypothetical protein. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.587 |
MMP1351 | MMP1350 | MMP1351 | MMP1350 | N-acetyltransferase domain-containing protein; Unnamed protein product. | Conserved hypothetical protein. | 0.953 |
MMP1351 | MMP1353 | MMP1351 | MMP1353 | N-acetyltransferase domain-containing protein; Unnamed protein product. | Conserved hypothetical protein. | 0.408 |
MMP1351 | thi4 | MMP1351 | MMP1352 | N-acetyltransferase domain-containing protein; Unnamed protein product. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.525 |
MMP1351 | thiI | MMP1351 | MMP1354 | N-acetyltransferase domain-containing protein; Unnamed protein product. | Thiamine biosynthesis protein:THUMP domain; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.406 |
MMP1353 | MMP0415 | MMP1353 | MMP0415 | Conserved hypothetical protein. | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | 0.430 |
MMP1353 | MMP1350 | MMP1353 | MMP1350 | Conserved hypothetical protein. | Conserved hypothetical protein. | 0.556 |
MMP1353 | MMP1351 | MMP1353 | MMP1351 | Conserved hypothetical protein. | N-acetyltransferase domain-containing protein; Unnamed protein product. | 0.408 |
MMP1353 | thi4 | MMP1353 | MMP1352 | Conserved hypothetical protein. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.556 |
MMP1353 | thiI | MMP1353 | MMP1354 | Conserved hypothetical protein. | Thiamine biosynthesis protein:THUMP domain; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.653 |
MMP1639 | thi4 | MMP1639 | MMP1352 | Acyl-CoA dehydrogenase. | NAD binding site:TonB-dependent receptor protein:Thiamine biosynthesis Thi4 protein; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.883 |