Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP1356Conserved hypothetical protein. (314 aa)    
Predicted Functional Partners:
MMP1357
ThiamineS.
  
 
 0.975
rpoD
DNA-directed RNA polymerase, subunit D.
  
 
 0.845
upp
Uracil Phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate; Belongs to the UPRTase family.
 
 
 0.843
thiI
Thiamine biosynthesis protein:THUMP domain; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
  
 0.830
MMP1234
Conserved hypothetical membrane related protein.
 
 
 0.826
comB
2-phosphosulfolactate phosphatase; Citation: Eur. J. Biochem. 268:5176-5188(2001).
   
 
 0.809
rpa
Replication protein A; Citation: PNAS (1998) 95: 14634-14639, Annu. Rev. Biochem. (1997) 66: 61-91.
       0.806
hat
Histone acetyltransferase.
   
 
 0.725
MMP0169
Conserved hypothetical protein.
  
  
 0.711
MMP1353
Conserved hypothetical protein.
  
 
 
0.681
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.