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aroD3-dehydroquinate dehydratase (Type I DHQase); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. (218 aa)    
Predicted Functional Partners:
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 0.999
aroB
Conserved hypothetical protein; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
 
  
 0.974
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.944
aroA
3-phosphoshikimate-1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.929
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 
 0.843
MMP1395
Helix-hairpin-helix motif:DEAD/DEAH box helicase:Helicase, C-terminal:Helix-hairpin-helix DNA-binding, class 1:ERCC4 domain.
  
  
 0.814
tyrA
Prephenate dehydrogenase; Citation: MacBeath G, Kast P, Hilvert D. (1998) Biochemistry 37:10062-73.
 
  
 0.786
trpG
Anthranilate synthase component II; Citation: Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN.(1999). Proc Natl Acad Sci. 96:9479-.
 
 
 0.760
aroQ
Chorismate mutase; Citation: MacBeath G, Kast P, Hilvert D. (1998). Biochemistry 37:10062-73.
  
  
 0.745
trpC
Indole-3-glycerol phosphate synthase; Citation: Knochel T, Pappenberger A, Jansonius JN, Kirschner K. (2002). J Biol Chem. 277:8626-34.
  
 
 0.735
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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