| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMP1425 | MMP1427 | MMP1425 | MMP1427 | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved Hypothetical Protein; Belongs to the UPF0210 family. | 0.731 |
| MMP1425 | dcd | MMP1425 | MMP1426 | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.767 |
| MMP1427 | MMP1425 | MMP1427 | MMP1425 | Conserved Hypothetical Protein; Belongs to the UPF0210 family. | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.731 |
| MMP1427 | dcd | MMP1427 | MMP1426 | Conserved Hypothetical Protein; Belongs to the UPF0210 family. | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.836 |
| dcd | MMP1425 | MMP1426 | MMP1425 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.767 |
| dcd | MMP1427 | MMP1426 | MMP1427 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Conserved Hypothetical Protein; Belongs to the UPF0210 family. | 0.836 |
| dcd | dut | MMP1426 | MMP1075 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | 0.908 |
| dcd | glyS | MMP1426 | MMP0212 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). | 0.716 |
| dcd | ndk | MMP1426 | MMP0283 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
| dcd | nrdD | MMP1426 | MMP0227 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Anaerobic Ribonucleoside-triphosphate reductase; Eliasson R, Fontecave M, Jornvall H, Krook M, Pontis E, Reichard P. (1990)Proc Natl Acad Sci U S A 87:3314-8; Citation: Science 273 (5278); 1058-1073 (1996). | 0.921 |
| dcd | pth2 | MMP1426 | MMP0609 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. | 0.689 |
| dcd | surE | MMP1426 | MMP1051 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
| dcd | thyA-2 | MMP1426 | MMP1379 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.929 |
| dcd | tmk | MMP1426 | MMP1034 | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate kinase. | 0.972 |
| dut | dcd | MMP1075 | MMP1426 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Bifunctional dCTP deaminase/dUTP diphosphatase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.908 |
| dut | ndk | MMP1075 | MMP0283 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.930 |
| dut | nrdD | MMP1075 | MMP0227 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Anaerobic Ribonucleoside-triphosphate reductase; Eliasson R, Fontecave M, Jornvall H, Krook M, Pontis E, Reichard P. (1990)Proc Natl Acad Sci U S A 87:3314-8; Citation: Science 273 (5278); 1058-1073 (1996). | 0.914 |
| dut | surE | MMP1075 | MMP1051 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.919 |
| dut | thyA-2 | MMP1075 | MMP1379 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. | 0.929 |
| dut | tmk | MMP1075 | MMP1034 | dUTP diphosphatase; Citation: J. Biol. Chem., Vol. 278, Issue 13, 11100-11106, March 28, 2003. | Thymidylate kinase. | 0.934 |