Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
2pgk2-phosphoglycerate kinase; Citation: Mol. Gen. Genet. 242 (2), 163-168 (1994); FEBS Lett. 272:94-98. (312 aa)    
Predicted Functional Partners:
MMP1217
Conserved hypothetical archaeal protein.
  
    0.854
MMP1218
Conserved hypothetical protein.
  
    0.850
comA
(2R)-phospho-3-sulfolactate synthase; Citation: J. Biol. Chem. 277:13421-13429(2002).
   
  
 0.829
MMP1430
Putative TRK system cation (K+) uptake protein; Citation: J Bacteriol. 1995 Apr;177(7):1908-10; Microbiol. 1998 144:2281-2289.
 
     0.776
MMP1605
Pyruvate kinase; Belongs to the pyruvate kinase family.
   
  
 0.715
comD
Sulfopyruvate decarboxylase subunit alpha; Involved in the biosynthesis of the coenzyme M (2- mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde; Belongs to the ComD family.
   
  
 0.702
mtrD
N5-methyltetrahydromethanopterin: methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
      
 0.648
apgM
2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
 
  
 0.631
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
  
  
 0.604
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
    0.600
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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