| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMP0173 | MMP1489 | MMP0173 | MMP1489 | Conserved hypothetical protein. | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | 0.733 |
| MMP0173 | pdaD | MMP0173 | MMP1582 | Conserved hypothetical protein. | Pyruvoyl-dependent arginine decarboxylase, PvlArgDC, alpha and beta subunits; Citation: Graham et al, J. Biol. Chem. 277:23500-23507(2002); Belongs to the PdaD family. | 0.417 |
| MMP1332 | MMP1489 | MMP1332 | MMP1489 | NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | 0.943 |
| MMP1332 | gap | MMP1332 | MMP0325 | NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Glyceraldehyde 3-phosphate dehydrogenase. | 0.610 |
| MMP1489 | MMP0173 | MMP1489 | MMP0173 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Conserved hypothetical protein. | 0.733 |
| MMP1489 | MMP1332 | MMP1489 | MMP1332 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | 0.943 |
| MMP1489 | MMP1578 | MMP1489 | MMP1578 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.932 |
| MMP1489 | dacZ | MMP1489 | MMP1479 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.841 |
| MMP1489 | dph5 | MMP1489 | MMP0588 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.711 |
| MMP1489 | gap | MMP1489 | MMP0325 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Glyceraldehyde 3-phosphate dehydrogenase. | 0.732 |
| MMP1489 | hisC | MMP1489 | MMP1216 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Histidinol-phosphate aminotransferase; Citation: Conover RK, Doolittle WF. (1990) J Bacteriol 172:3244-9. | 0.789 |
| MMP1489 | mptA | MMP1489 | MMP0034 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Conserved hypothetical protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.843 |
| MMP1489 | nadE | MMP1489 | MMP1349 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | NAD+ synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.965 |
| MMP1489 | pdaD | MMP1489 | MMP1582 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Pyruvoyl-dependent arginine decarboxylase, PvlArgDC, alpha and beta subunits; Citation: Graham et al, J. Biol. Chem. 277:23500-23507(2002); Belongs to the PdaD family. | 0.732 |
| MMP1578 | MMP1489 | MMP1578 | MMP1489 | Cytidylyltransferase:Cytidyltransferase-related domain. | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | 0.932 |
| MMP1578 | gap | MMP1578 | MMP0325 | Cytidylyltransferase:Cytidyltransferase-related domain. | Glyceraldehyde 3-phosphate dehydrogenase. | 0.441 |
| MMP1578 | nadE | MMP1578 | MMP1349 | Cytidylyltransferase:Cytidyltransferase-related domain. | NAD+ synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.982 |
| dacZ | MMP1489 | MMP1479 | MMP1489 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | 0.841 |
| dacZ | dph5 | MMP1479 | MMP0588 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.716 |
| dacZ | hisC | MMP1479 | MMP1216 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Histidinol-phosphate aminotransferase; Citation: Conover RK, Doolittle WF. (1990) J Bacteriol 172:3244-9. | 0.751 |
