Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hsp60Chaperonin GroEL (thermosome, HSP60 family); Belongs to the TCP-1 chaperonin family. (543 aa)    
Predicted Functional Partners:
lon
ATP-dependent Lon protease; Eukaryotic thiol (cysteine) protease, active site:ATP/GTP-binding site motif A (P-loop):Sigma-54 factor interaction domain:Pu..; Belongs to the peptidase S16 family.
  
 0.971
mdh
Malate dehydrogenase, MDHII (NADP+-dependent); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.954
pdfA
Prefoldin alpha subunit (GimC alpha subunit); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
   
 0.946
pfdB
Prefoldin beta subunit (GimC beta subunit); Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
 0.931
rps2
SSU Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
 
 0.929
MMP0176
CDC48 cell division cycle protein family member; ATP/GTP-binding site motif A (P-loop); Citation: Mol. Gen. Genet. (1999) 262: 559-567, Cell (1995) 82: 885-893.
 
 0.924
aEF-2
Translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF- [...]
 
 
 0.920
gapN
Aldehyde dehydrogenase; Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.
  
 0.914
hsp20
Heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family.
  
  
 0.907
psmA
Proteasome, subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
 
 
 0.886
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.