Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP1525Modulator of DNA gyrase. (420 aa)    
Predicted Functional Partners:
MMP1488
Modulator of DNA gyrase.
 
  
0.816
lon
ATP-dependent Lon protease; Eukaryotic thiol (cysteine) protease, active site:ATP/GTP-binding site motif A (P-loop):Sigma-54 factor interaction domain:Pu..; Belongs to the peptidase S16 family.
  
  
 0.704
MMP1028
NFACT-R_1 domain-containing protein; Unnamed protein product.
   
    0.695
rncS
Ribonuclease III family:Double-stranded RNA binding (DsRBD) domain.
  
  
 0.675
secD
SecD/SecF/SecDF export membrane protein; Involved in protein export.
     
 0.598
secF
SecD/SecF/SecDF export membrane protein; Involved in protein export.
       0.557
MMP1332
NAD binding site:FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
  
 0.472
purB
Adenylosuccinate lyase; Citation: Toth EA, Worby C, Dixon JE, Goedken ER, Marqusee S, Yeates TO. (2000) J Mol Biol 301:433-50; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
  
 0.452
hypD
Hydrogenase expression/formation protein.
       0.447
cofG
FO synthase, subunit CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
  
    0.446
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (28%) [HD]