| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMP0174 | MMP1288 | MMP0174 | MMP1288 | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | Unnamed protein product. | 0.628 |
| MMP0174 | MMP1663 | MMP0174 | MMP1663 | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | Conserved hypothetical protein. | 0.624 |
| MMP0174 | cbiT | MMP0174 | MMP1221 | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | SAM (and some other nucleotide) binding motif; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.442 |
| MMP0174 | cofD | MMP0174 | MMP0404 | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | LPPG:FO 2-phospho-(S)-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.689 |
| MMP0174 | ubiX | MMP0174 | MMP1552 | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.734 |
| MMP0415 | MMP1663 | MMP0415 | MMP1663 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Conserved hypothetical protein. | 0.827 |
| MMP0415 | ffh | MMP0415 | MMP1551 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Signal recognition particle protein SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.849 |
| MMP0415 | ubiX | MMP0415 | MMP1552 | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.827 |
| MMP1064 | ubiX | MMP1064 | MMP1552 | RNA-binding region RNP-1 (RNA recognition motif):Adenylate cyclase. | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.689 |
| MMP1288 | MMP0174 | MMP1288 | MMP0174 | Unnamed protein product. | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | 0.628 |
| MMP1288 | MMP1645 | MMP1288 | MMP1645 | Unnamed protein product. | Amino acid kinase related protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | 0.914 |
| MMP1288 | MMP1663 | MMP1288 | MMP1663 | Unnamed protein product. | Conserved hypothetical protein. | 0.763 |
| MMP1288 | ubiX | MMP1288 | MMP1552 | Unnamed protein product. | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.997 |
| MMP1645 | MMP1288 | MMP1645 | MMP1288 | Amino acid kinase related protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | Unnamed protein product. | 0.914 |
| MMP1645 | ubiX | MMP1645 | MMP1552 | Amino acid kinase related protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.906 |
| MMP1663 | MMP0174 | MMP1663 | MMP0174 | Conserved hypothetical protein. | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | 0.624 |
| MMP1663 | MMP0415 | MMP1663 | MMP0415 | Conserved hypothetical protein. | Eukaryotic protein kinase:Glycoprotease (M22) metalloprotease:Tyrosine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the [...] | 0.827 |
| MMP1663 | MMP1288 | MMP1663 | MMP1288 | Conserved hypothetical protein. | Unnamed protein product. | 0.763 |
| MMP1663 | ubiX | MMP1663 | MMP1552 | Conserved hypothetical protein. | Flavoprotein:Phenylacrylic acid decarboxylase, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.689 |
| cbiT | MMP0174 | MMP1221 | MMP0174 | SAM (and some other nucleotide) binding motif; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | HD phosphohydrolase family member; Citation: L. Aravind and E.V. Koonin, Trends Biochem. Sci. 23, 469 (1998). | 0.442 |