| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMP0329 | MMP1578 | MMP0329 | MMP1578 | Conserved archaeal hypothetical protein. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.827 |
| MMP1425 | MMP1578 | MMP1425 | MMP1578 | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.867 |
| MMP1425 | tiaS | MMP1425 | MMP0616 | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | OB-fold nucleic acid binding domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.650 |
| MMP1489 | MMP1578 | MMP1489 | MMP1578 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.932 |
| MMP1489 | nadE | MMP1489 | MMP1349 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | NAD+ synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.965 |
| MMP1489 | surE | MMP1489 | MMP1051 | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.684 |
| MMP1578 | MMP0329 | MMP1578 | MMP0329 | Cytidylyltransferase:Cytidyltransferase-related domain. | Conserved archaeal hypothetical protein. | 0.827 |
| MMP1578 | MMP1425 | MMP1578 | MMP1425 | Cytidylyltransferase:Cytidyltransferase-related domain. | Protein of unknown function DUF127; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.867 |
| MMP1578 | MMP1489 | MMP1578 | MMP1489 | Cytidylyltransferase:Cytidyltransferase-related domain. | Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily. | 0.932 |
| MMP1578 | lon | MMP1578 | MMP1186 | Cytidylyltransferase:Cytidyltransferase-related domain. | ATP-dependent Lon protease; Eukaryotic thiol (cysteine) protease, active site:ATP/GTP-binding site motif A (P-loop):Sigma-54 factor interaction domain:Pu..; Belongs to the peptidase S16 family. | 0.738 |
| MMP1578 | nadA | MMP1578 | MMP1242 | Cytidylyltransferase:Cytidyltransferase-related domain. | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.838 |
| MMP1578 | nadC | MMP1578 | MMP0877 | Cytidylyltransferase:Cytidyltransferase-related domain. | Quinolinate phosphoribosyl transferase:Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.990 |
| MMP1578 | nadE | MMP1578 | MMP1349 | Cytidylyltransferase:Cytidyltransferase-related domain. | NAD+ synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.982 |
| MMP1578 | nadX | MMP1578 | MMP0737 | Cytidylyltransferase:Cytidyltransferase-related domain. | Protein of unknown function DUF108; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. | 0.787 |
| MMP1578 | surE | MMP1578 | MMP1051 | Cytidylyltransferase:Cytidyltransferase-related domain. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.908 |
| MMP1578 | tiaS | MMP1578 | MMP0616 | Cytidylyltransferase:Cytidyltransferase-related domain. | OB-fold nucleic acid binding domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.699 |
| lon | MMP1578 | MMP1186 | MMP1578 | ATP-dependent Lon protease; Eukaryotic thiol (cysteine) protease, active site:ATP/GTP-binding site motif A (P-loop):Sigma-54 factor interaction domain:Pu..; Belongs to the peptidase S16 family. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.738 |
| nadA | MMP1578 | MMP1242 | MMP1578 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | Cytidylyltransferase:Cytidyltransferase-related domain. | 0.838 |
| nadA | nadC | MMP1242 | MMP0877 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | Quinolinate phosphoribosyl transferase:Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.999 |
| nadA | nadE | MMP1242 | MMP1349 | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | NAD+ synthase related protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.834 |