Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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pdaDPyruvoyl-dependent arginine decarboxylase, PvlArgDC, alpha and beta subunits; Citation: Graham et al, J. Biol. Chem. 277:23500-23507(2002); Belongs to the PdaD family. (164 aa)    
Predicted Functional Partners:
MMP1585
Arginase; Belongs to the arginase family.
 
 
 0.972
speE
SAM (and some other nucleotide) binding motif:Spermine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
  
  
 0.936
speH
S-adenosylmethionine decarboxylase related; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
  
  
 0.934
argH
Argininosuccinate lyase; Citation: R. Cohen Kupiec et. al. FEMS Microbiol Lett. 173, 231-238 (1999).
   
 
  0.816
trm1
N2;N2-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
      
 0.801
MMP1489
Inositol monophosphate related protein; Involved in the regulation of the intracellular balance between NAD(H) and NADP(H), and is a key enzyme in the biosynthesis of NADP. Catalyzes the phosphorylation and dephosphorylation of NAD and NADP, respectively. Although it shows conflicting dual activities and is able to supply NADP, it seems that its physiological role is to prevent excess accumulation of NADP (By similarity); In the N-terminal section; belongs to the inositol monophosphatase superfamily.
 
     0.732
hmgA
Hydroxymethylglutaryl-coenzyme A reductase:3-hydroxy-3-methylglutaryl Coenzyme A reductase; Citation: Protein Expr Purif. 1999 Dec;17(3):435-42, Mol Biol Evol. 2001 Jul;18(7):1378-88; Belongs to the HMG-CoA reductase family.
      
 0.690
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
   
 0.622
aIF-5A
Translation initiation factor IF-5a; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
  
  
 0.619
leuS
Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.565
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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