Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP1597Family of unknown function DUF64. (169 aa)    
Predicted Functional Partners:
cobS
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
 0.709
cobY/cofC
Nucleoside triphosphate: 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase; Appears to catalyze the guanylation of both (S)-2-phospholactate and adenosylcobinamide phosphate; Citation: M. G. Thomas and J. C. Escalante-Semerena, J. Bacteriol., 2000, 182, 4227; Nat. Prod. Rep., 2002, 19(2), 133 - 147.
       0.689
hisC
Histidinol-phosphate aminotransferase; Citation: Conover RK, Doolittle WF. (1990) J Bacteriol 172:3244-9.
     
 0.641
chiB
Cobalamin biosynthesis protein B; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
     
 0.636
MMP1596
Conserved Hypothetical Archael protein.
  
    0.633
trkA
Trk system potassium uptake protein A; Citation: Macario, A.J.L., Dugan, C.B., and Conway de Macario, E. 1216:495-498,1994.
       0.630
MMP0338
Phosphoribosyltransferase related protein; Belongs to the UPF0284 family.
       0.616
MMP1598
Conserved hypothetical protein.
       0.564
MMP1595
Archaeosine synthase alpha-subunit; ATP/GTP-binding site motif A (P-loop):PUA domain:Queuine/other tRNA-ribosyltransferase:Uncharacterized domain 2.
  
    0.488
asnB
Asparagine synthetase (glutamine-hydrolyzing); Citation: Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. (1999) Biochemistry 38:16146-57.
       0.457
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.