STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metHaProbable 5-methyltetrahydrofolate--homocysteine methyltransferase (methionine synthase, vitamin-b12 dependent isozyme) protein. (346 aa)    
Predicted Functional Partners:
metHb
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 0.999
metF
Probable 5,10-methylenetetrahydrofolate reductase oxidoreductase protein; Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.985
metE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.982
metY
Probable o-acetylhomoserine (thiol)-lyase (methionine/homocysteine synthase) protein.
  
 
 0.968
metC
Putative cystathionine beta-lyase (cysteine lyase) protein.
  
 
 0.944
RSp0781
Probable cystathionine beta-lyases/cystathionine gamma-synthases protein.
  
 
 0.944
ahcY
Probable adenosylhomocysteinase (s-adenosyl-l-homocysteinehydrolase) (adohcyase) protein; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.940
metK
S-adenosylmethionine synthetase (methionineadenosyltransferase) (adomet synthetase) (mat) protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.935
RSp1583
Probable o-acetylhomoserine sulfhydrylase transmembrane protein.
  
 
 0.917
glyA1
Probable serine hydroxymethyltransferase 1 (serine methylase 1)(shmt 1) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.916
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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