STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hprKPutative hpr kinase/phosphorylase (hprk/p) (hpr(ser)kinase/phosphorylase) protein; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (324 aa)    
Predicted Functional Partners:
ptsI
Probable phosphoenolpyruvate-protein phosphotransferase transmembrane; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.952
ptsN
Nitrogen PTS system EIIA component; Putative nitrogen regulatory IIa (enzyme IIa-ntr) (phosphotransferase enzyme II, a component) transcription regulator protein.
 
  
 0.926
pstH
Probable phosphocarrier protein hpr (phosphohistidinoprotein-hexose phosphotransferase).
 
 
 
 0.878
uvrB
Probable uvrabc system protein b (uvrb protein) (excinuclease abc subunit b); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. [...]
    
 0.802
lptA
Putative signal peptide protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.
 
   
 0.792
RSp1282
Probable pts system, fructose-specific eIIa/hpr/ei components protein.
 
 
 
 0.788
fruB
Probable multiphosphoryl transfer protein mtp.
 
 
 
 0.721
RSc0346
Putative pts system fructose subfamily IIa component; protein.
 
  
 0.715
pgl
Probable 6-phosphogluconolactonase oxidoreductase protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
  
  
 0.646
lgt
Probable prolipoprotein diacylglyceryl transferase. transmembrane; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
  
  
 0.644
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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