STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
iscSProbable cysteine sulfinate desulfinase / cysteine desulfurase protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (405 aa)    
Predicted Functional Partners:
iscU
Probable iron-binding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
RSc1018
Putative of unknown function upf0074; transcription regulator protein.
  
 0.995
sirA
Probable redox protein, regulator of disulfide bond formation; Belongs to the sulfur carrier protein TusA family.
   
 0.983
hscB
Probable co-chaperone protein hscb homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.; Belongs to the HscB family.
 
 0.982
fdx
Probable ferredoxin [2fe-2s] protein.
 
 0.976
iscA
Conserved hypothetical protein; Miscellaneous; hypothetical/global homology; Belongs to the HesB/IscA family.
 
 
 0.958
thiF
Putative thif transmembrane protein.
   
 0.955
hscA
Probable chaperone protein hsca homolog; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 0.944
cyaY
Probable protein cyay; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 0.927
sseA
Probable thiosulfate sulfurtransferase protein.
  
 0.925
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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