Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
iscAConserved hypothetical protein; Miscellaneous; hypothetical/global homology; Belongs to the HesB/IscA family. (106 aa)    
Predicted Functional Partners:
iscU
Probable iron-binding protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.991
hscB
Probable co-chaperone protein hscb homolog; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.; Belongs to the HscB family.
 
 
 0.988
fdx
Probable ferredoxin [2fe-2s] protein.
 
 0.959
iscS
Probable cysteine sulfinate desulfinase / cysteine desulfurase protein; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
 
 0.958
RSc1018
Putative of unknown function upf0074; transcription regulator protein.
  
  
 0.888
hscA
Probable chaperone protein hsca homolog; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 
 0.883
RSc1026
Hypothetical protein of unknown function duf528.
 
  
 0.849
RSp0173
Putative cysteine desulfurase (trna sulfurtransferase) protein.
 
 
 0.842
RSc1782
Putative glycine cleavage t protein (aminomethyl transferase); Belongs to the GcvT family.
 
 
 0.817
RSc1022
Conserved hypothetical protein; Miscellaneous; hypothetical/global homology.
       0.741
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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