| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RSp0787 | bioF | RSp0787 | RSc1478 | Putative amp-dependent synthetase and ligase transmembrane protein. | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.876 |
| RSp0960 | bioF | RSp0960 | RSc1478 | Putative nad-dependent epimerase/dehydratase protein. | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.683 |
| bioA | bioB | RSc1477 | RSc0266 | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.997 |
| bioA | bioD | RSc1477 | RSc1479 | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
| bioA | bioF | RSc1477 | RSc1478 | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.995 |
| bioB | bioA | RSc0266 | RSc1477 | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.997 |
| bioB | bioD | RSc0266 | RSc1479 | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
| bioB | bioF | RSc0266 | RSc1478 | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.894 |
| bioB | thiG | RSc0266 | RSc0109 | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Thiazole biosynthesis protein thig; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.526 |
| bioD | bioA | RSc1479 | RSc1477 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.999 |
| bioD | bioB | RSc1479 | RSc0266 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Probable biotin synthase protein; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.999 |
| bioD | bioF | RSc1479 | RSc1478 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.992 |
| bioD | cbiD | RSc1479 | RSp0622 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Putative cobalt-precorrin-6a synthase [deacetylating]. transmembrane protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.625 |
| bioD | hemC | RSc1479 | RSc2357 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.623 |
| bioD | nadC | RSc1479 | RSc2448 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Probable nicotinate-nucleotide pyrophosphorylase (carboxylating) quinolinate phosphoribosyltransferase (decarboxylating) protein; Belongs to the NadC/ModD family. | 0.746 |
| bioD | ribH | RSc1479 | RSc0712 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.721 |
| bioD | thiG | RSc1479 | RSc0109 | Probable dethiobiotin synthetase (dethiobiotin synthase) (dtbsynthetase) (dtbs) protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Thiazole biosynthesis protein thig; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.791 |
| bioF | RSp0787 | RSc1478 | RSp0787 | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Putative amp-dependent synthetase and ligase transmembrane protein. | 0.876 |
| bioF | RSp0960 | RSc1478 | RSp0960 | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Putative nad-dependent epimerase/dehydratase protein. | 0.683 |
| bioF | bioA | RSc1478 | RSc1477 | Probable 8-amino-7-oxononanoate synthase protein; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Probable adenosylmethionine-8-amino-7-oxononanoate aminotransferase protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.995 |