STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Coexpression
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[Homology]
Score
prpB1Probable carboxyvinyl-carboxyphosphonate phosphorylmutase protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (303 aa)    
Predicted Functional Partners:
prpC
Probable methylcitrate synthase (citrate synthase 2) protein; Belongs to the citrate synthase family.
 
 0.987
acnB
Probable aconitate hydratase 2 transmembrane protein; Belongs to the aconitase/IPM isomerase family.
   
 
 0.960
prpD
Probable prpd protein.
 
  
 0.958
acnA1
Probable aconitate hydratase protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.952
acnA3
Probable aconitate hydratase 1 protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.934
aceA
Probable isocitrate lyase protein.
  
  
0.929
aceB
Probable malate synthase a (msa or masy protein); Belongs to the malate synthase family.
   
 0.925
sucD
Probable succinyl-coa synthetase alpha chain protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.915
sucC
Probable succinyl-coa synthetase beta chain (scs-beta) protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
   
 
 0.910
prpB2
Putative carboxyvinyl-carboxyphosphonate phosphorylmutase protein; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
  
 
0.902
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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