| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RSc2462 | dfp | RSc2462 | RSc2461 | Putative bacterial luciferase-likee oxidoreductase protein. | Probable dna/pantothenate metabolism flavoprotein flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.773 |
| RSc2462 | dut | RSc2462 | RSc2463 | Putative bacterial luciferase-likee oxidoreductase protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.791 |
| dcd | dut | RSc2366 | RSc2463 | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.931 |
| dcd | ndk | RSc2366 | RSc1211 | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. | Probable nucleoside diphosphate kinase (ndk) (ndp kinase)(nucleoside-2-p kinase) protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.930 |
| dcd | nrdD | RSc2366 | RSp0963 | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. | Putative ribonucleotide reductase oxidoreductase protein. | 0.905 |
| dcd | tmk | RSc2366 | RSc1784 | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. | Probable thymidylate kinase (dtmp kinase) protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.477 |
| dfp | RSc2462 | RSc2461 | RSc2462 | Probable dna/pantothenate metabolism flavoprotein flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Putative bacterial luciferase-likee oxidoreductase protein. | 0.773 |
| dfp | dut | RSc2461 | RSc2463 | Probable dna/pantothenate metabolism flavoprotein flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.992 |
| dnaN | dut | RSc3441 | RSc2463 | Probable dna polymerase III (beta chain) protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required f [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.888 |
| dnaN | nrdA | RSc3441 | RSc2805 | Probable dna polymerase III (beta chain) protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required f [...] | Putative ribonucleoside reductase 1 (large chain) oxidoreductase protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.761 |
| dnaN | thyA | RSc3441 | RSc0947 | Probable dna polymerase III (beta chain) protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required f [...] | Probable thymidylate synthase (ts) (tsase) protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.787 |
| dut | RSc2462 | RSc2463 | RSc2462 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative bacterial luciferase-likee oxidoreductase protein. | 0.791 |
| dut | dcd | RSc2463 | RSc2366 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable deoxycytidine triphosphate deaminase (dctp deaminase) protein; Catalyzes the deamination of dCTP to dUTP. | 0.931 |
| dut | dfp | RSc2463 | RSc2461 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable dna/pantothenate metabolism flavoprotein flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.992 |
| dut | dnaN | RSc2463 | RSc3441 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable dna polymerase III (beta chain) protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required f [...] | 0.888 |
| dut | ndk | RSc2463 | RSc1211 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable nucleoside diphosphate kinase (ndk) (ndp kinase)(nucleoside-2-p kinase) protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.940 |
| dut | nrdA | RSc2463 | RSc2805 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative ribonucleoside reductase 1 (large chain) oxidoreductase protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.821 |
| dut | nrdD | RSc2463 | RSp0963 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative ribonucleotide reductase oxidoreductase protein. | 0.918 |
| dut | surE | RSc2463 | RSc1204 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable 5'-nucleotidase sure (nucleoside 5'-monophosphatephosphohydrolase) protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
| dut | thyA | RSc2463 | RSc0947 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dutpase) (dutp pyrophosphatase) protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable thymidylate synthase (ts) (tsase) protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.986 |