STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Coexpression
Experiments
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[Homology]
Score
icdProbable isocitrate dehydrogenase [nadp] oxidoreductase protein. (416 aa)    
Predicted Functional Partners:
acnA3
Probable aconitate hydratase 1 protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.991
acnA1
Probable aconitate hydratase protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.989
mdh
Probable malate dehydrogenase. oxidoreductase protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.983
acnB
Probable aconitate hydratase 2 transmembrane protein; Belongs to the aconitase/IPM isomerase family.
  
 
 0.979
odhA
Probable oxoglutarate dehydrogenase oxidoreductase protein.
   
 0.973
sucA
Probable 2-oxoglutarate dehydrogenase e1 decarboxylase component oxidoreductase protein.
   
 0.973
fumA
Probable fumarate hydratase protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.961
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.924
prpC
Probable methylcitrate synthase (citrate synthase 2) protein; Belongs to the citrate synthase family.
  
 0.923
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
 
 
 0.912
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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