STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icdProbable isocitrate dehydrogenase [nadp] oxidoreductase protein. (416 aa)    
Predicted Functional Partners:
acnB
Probable aconitate hydratase 2 transmembrane protein; Belongs to the aconitase/IPM isomerase family.
  
 
 0.979
acnA3
Probable aconitate hydratase 1 protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.978
acnA1
Probable aconitate hydratase protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.977
fumA
Probable fumarate hydratase protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.972
odhA
Probable oxoglutarate dehydrogenase oxidoreductase protein.
   
 
 0.969
sucA
Probable 2-oxoglutarate dehydrogenase e1 decarboxylase component oxidoreductase protein.
   
 
 0.969
gdhA
Probable glutamate dehydrogenase (nad(p)+) oxidoreductase protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.961
mdh
Probable malate dehydrogenase. oxidoreductase protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.944
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
 
 
 0.914
gltB
Probable glutamate synthase (large subunit) oxidoreductase protein.
    
 0.899
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.