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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 0.999
hisA
Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein.
 
 0.999
hisB
Probable imidazoleglycerol-phosphate dehydratase (igpd). oxidoreductase protein.
 
 0.999
hisD
Probable histidinol dehydrogenase (hdh). oxidoreductase protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.994
hisI
Probable phosphoribosyl-amp cyclohydrolase (pra-ch) protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.992
hisE
Probable phosphoribosyl-atp pyrophosphatase (pra-ph) protein.
 
  
 0.990
hisC1
Probable histidinol-phosphate aminotransferase 1 (imidazoleacetol-phosphate transaminase 1) protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.962
hisZ
Putative atp phosphoribosyltransferase involved in histidine biosynthesis protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
 
  
 0.938
hisC2
Probable histidinol-phosphate aminotransferase 2 (imidazoleacetol-phosphate transaminase 2) protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
  
 0.872
purH
Probable bifunctional purine biosynthesis purh [includes:phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase); imp cyclohydrolase (inosinicase) (imp synthetase) (atic)]. transmembrane protein.
    
 0.859
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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