node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RSc1271 | gcvH | RSc1271 | RSc3294 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.982 |
RSc1271 | gcvP | RSc1271 | RSc3295 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.960 |
RSc1271 | gcvT | RSc1271 | RSc3293 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable aminomethyltransferase (glycine cleavage system tprotein); The glycine cleavage system catalyzes the degradation of glycine. | 0.947 |
RSc1271 | glyA1 | RSc1271 | RSc0729 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable serine hydroxymethyltransferase 1 (serine methylase 1)(shmt 1) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
RSc1271 | glyA2 | RSc1271 | RSp0055 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable serine hydroxymethyltransferase 2 (serine methylase 2)(shmt 2) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
RSc1271 | lpdA | RSc1271 | RSc1603 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable dihydrolipoamide dehydrogenase (e3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.984 |
RSc1271 | soxA1 | RSc1271 | RSp0048 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.522 |
RSc1271 | soxA2 | RSc1271 | RSc1103 | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.522 |
gcvH | RSc1271 | RSc3294 | RSc1271 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | 0.982 |
gcvH | gcvP | RSc3294 | RSc3295 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | RSc3294 | RSc3293 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable aminomethyltransferase (glycine cleavage system tprotein); The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA1 | RSc3294 | RSc0729 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable serine hydroxymethyltransferase 1 (serine methylase 1)(shmt 1) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
gcvH | glyA2 | RSc3294 | RSp0055 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable serine hydroxymethyltransferase 2 (serine methylase 2)(shmt 2) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
gcvH | lpdA | RSc3294 | RSc1603 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable dihydrolipoamide dehydrogenase (e3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.996 |
gcvH | purD | RSc3294 | RSc2191 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable phosphoribosylamine--glycine ligase (gars) (glycinamideribonucleotide synthetase) (phosphoribosylglycinamide synthetase) protein. | 0.459 |
gcvH | purL | RSc3294 | RSc1722 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.530 |
gcvH | soxA1 | RSc3294 | RSp0048 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.960 |
gcvH | soxA2 | RSc3294 | RSc1103 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.955 |
gcvP | RSc1271 | RSc3295 | RSc1271 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Probable dihydrolipoamide dehydrogenase (component of pyruvate and 2-oxoglutarate dehydrogenases complexes) oxidoreductase protein. | 0.960 |
gcvP | gcvH | RSc3295 | RSc3294 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |