node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folD | gcvH | RSc1596 | RSc3294 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.794 |
folD | gcvP | RSc1596 | RSc3295 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.871 |
folD | gcvT | RSc1596 | RSc3293 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable aminomethyltransferase (glycine cleavage system tprotein); The glycine cleavage system catalyzes the degradation of glycine. | 0.958 |
folD | glyA2 | RSc1596 | RSp0055 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable serine hydroxymethyltransferase 2 (serine methylase 2)(shmt 2) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
folD | lpdA | RSc1596 | RSc1603 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable dihydrolipoamide dehydrogenase (e3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.570 |
folD | purH | RSc1596 | RSc0504 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable bifunctional purine biosynthesis purh [includes:phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase); imp cyclohydrolase (inosinicase) (imp synthetase) (atic)]. transmembrane protein. | 0.979 |
folD | purL | RSc1596 | RSc1722 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.833 |
folD | purN | RSc1596 | RSc2454 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable phosphoribosylglycinamide formyltransferase protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.966 |
folD | soxA1 | RSc1596 | RSp0048 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.690 |
folD | soxA2 | RSc1596 | RSc1103 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.690 |
gcvH | folD | RSc3294 | RSc1596 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.794 |
gcvH | gcvP | RSc3294 | RSc3295 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | RSc3294 | RSc3293 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable aminomethyltransferase (glycine cleavage system tprotein); The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA2 | RSc3294 | RSp0055 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable serine hydroxymethyltransferase 2 (serine methylase 2)(shmt 2) protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
gcvH | lpdA | RSc3294 | RSc1603 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable dihydrolipoamide dehydrogenase (e3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) protein. | 0.996 |
gcvH | purH | RSc3294 | RSc0504 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable bifunctional purine biosynthesis purh [includes:phosphoribosylaminoimidazolecarboxamide formyltransferase (aicar transformylase); imp cyclohydrolase (inosinicase) (imp synthetase) (atic)]. transmembrane protein. | 0.430 |
gcvH | purL | RSc3294 | RSc1722 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.530 |
gcvH | soxA1 | RSc3294 | RSp0048 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.960 |
gcvH | soxA2 | RSc3294 | RSc1103 | Probable glycine cleavage system h protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Probable sarcosine oxidase (alpha subunit) oxidoreductase protein; Belongs to the GcvT family. | 0.955 |
gcvP | folD | RSc3295 | RSc1596 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.871 |