STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA22-isopropylmalate synthase 2; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (576 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.990
dmpF
Probable acetaldehyde dehydrogenase oxidoreductase protein; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 0.980
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.974
ilvD
Probable dihydroxy-acid dehydratase protein; Belongs to the IlvD/Edd family.
  
 
 0.957
ilvE
Probable branched-chain amino acid aminotransferase protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 0.955
ilvE3
Probable branched-chain amino acid aminotransferase protein.
  
 0.955
ilvH
Probable acetolactate synthase isozyme III (small subunit) protein.
 
 
 0.938
RSc0276
Probable acetyl-coa acetyltransferase (acetoacetyl-coa thiolase) protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
phbA
Probable acetyl-coa acetyltransferase (acetoacetyl-coa thiolase) protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
bktB
Probable beta-ketothiolase protein; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.919
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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