STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
epsCUdp-n-acetylglucosamine 2-epimerase (udp-glcnac-2-epimerase) protein; May be involved in synthesis of N-acetyltrideoxygalactose, a component of exopolysaccharide EPS I which functions as a virulence factor; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (379 aa)    
Predicted Functional Partners:
epsD
Ndp-n-acetyl-d-galactosaminuronic acid dehydrogenase. oxidoreductase protein; Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N-acetyl-D- galactosaminuronic acid.
 
 0.999
epsE
epsIpolysaccharide export inner membrane epse. transmembrane protein; Probably involved in polymerization and/or export of exopolysaccharide EPS I which functions as a virulence factor. May play a role in export of EPS I or its intermediates across the membranes (By similarity); To E.coli bicyclomycin resistance protein (BCR).
  
  
 0.930
glmU
Probable udp-n-acetylglucosamine pyrophosphorylase protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat [...]
    
 0.921
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
  
 
 0.912
epsC2
Probable udp-n-acetylglucosamine 2-epimerase protein; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
  
  
 
0.901
epsB
Putative tyrosine-protein kinase epsb (eps ipolysaccharide export epsb). transmembrane; Probably involved in polymerization and/or export of exopolysaccharide EPS I which functions as a virulence factor. May be involved in an ATP-dependent process in the pathway for EPS I production, possibly export of the trimeric repeat units across the inner membrane or their polymerization (By similarity).
     
 0.868
galU1
Probable utp--glucose-1-phosphate uridylyltransferase protein.
  
 
 0.848
galU2
Probable utp--glucose-1-phosphate uridylyltransferase udp-glucose pyrophosphorylase protein.
  
 
 0.848
rfbA
Probable glucose-1-phosphate thymidylyltransferase protein; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
 0.832
lpxA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
    
  0.812
Your Current Organism:
Ralstonia solanacearum
NCBI taxonomy Id: 267608
Other names: R. solanacearum GMI1000, Ralstonia solanacearum GMI1000, Ralstonia solanacearum str. GMI1000, Ralstonia solanacearum strain GMI1000
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