| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMOB1460 | ffh | MMOB1460 | MMOB5270 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.900 |
| MMOB1460 | ftsY | MMOB1460 | MMOB1380 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | Cell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.911 |
| MMOB1460 | secA | MMOB1460 | MMOB0860 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | Preprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.900 |
| MMOB1460 | secDF | MMOB1460 | MMOB2720 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | secD- and secF-like type II secretion system protein; COG0341; COG0342; expression validated by proteogenomic mapping: 11 unique peptides covering 17.5% of sequence. | 0.900 |
| MMOB1460 | secY | MMOB1460 | MMOB2540 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | Preprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.900 |
| MMOB1460 | yidC | MMOB1460 | MMOB6300 | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | Putative preprotein translocase subunit; COG0706; expression validated by proteogenomic mapping: 14 unique peptides covering 16.6% of sequence. | 0.900 |
| acpP | polA | MMOB2200 | MMOB4880 | Acyl carrier protein; COG0236; expression validated by proteogenomic mapping: 7 unique peptides covering 69.6% of sequence. | DNA polymerase I; COG0258; expression validated by proteogenomic mapping: 13 unique peptides covering 33.9% of sequence. | 0.726 |
| acpP | secA | MMOB2200 | MMOB0860 | Acyl carrier protein; COG0236; expression validated by proteogenomic mapping: 7 unique peptides covering 69.6% of sequence. | Preprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.785 |
| acpP | yidC | MMOB2200 | MMOB6300 | Acyl carrier protein; COG0236; expression validated by proteogenomic mapping: 7 unique peptides covering 69.6% of sequence. | Putative preprotein translocase subunit; COG0706; expression validated by proteogenomic mapping: 14 unique peptides covering 16.6% of sequence. | 0.737 |
| ffh | MMOB1460 | MMOB5270 | MMOB1460 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | 0.900 |
| ffh | ftsY | MMOB5270 | MMOB1380 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Cell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.996 |
| ffh | polA | MMOB5270 | MMOB4880 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | DNA polymerase I; COG0258; expression validated by proteogenomic mapping: 13 unique peptides covering 33.9% of sequence. | 0.506 |
| ffh | rplW | MMOB5270 | MMOB2370 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 50S ribosomal protein l23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.872 |
| ffh | rpmC | MMOB5270 | MMOB2430 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 50S ribosomal protein l29; COG0255; expression validated by proteogenomic mapping: 6 unique peptides covering 45.2% of sequence; Belongs to the universal ribosomal protein uL29 family. | 0.876 |
| ffh | secA | MMOB5270 | MMOB0860 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Preprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.964 |
| ffh | secDF | MMOB5270 | MMOB2720 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | secD- and secF-like type II secretion system protein; COG0341; COG0342; expression validated by proteogenomic mapping: 11 unique peptides covering 17.5% of sequence. | 0.943 |
| ffh | secY | MMOB5270 | MMOB2540 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Preprotein translocase secY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.971 |
| ffh | yidC | MMOB5270 | MMOB6300 | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Putative preprotein translocase subunit; COG0706; expression validated by proteogenomic mapping: 14 unique peptides covering 16.6% of sequence. | 0.971 |
| ftsY | MMOB1460 | MMOB1380 | MMOB1460 | Cell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Hypothetical protein; Expression not validated; Belongs to the SecE/SEC61-gamma family. | 0.911 |
| ftsY | ffh | MMOB1380 | MMOB5270 | Cell division protein ftsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.996 |
