Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
parCTopoisomerase IV subunit A; COG0188; expression validated by proteogenomic mapping: 38 unique peptides covering 44.8% of sequence. (858 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit b; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 
 0.969
parE
Topoisomerase IB subunit B; COG0187; expression validated by proteogenomic mapping: 31 unique peptides covering 45% of sequence.
 
 
 0.956
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
0.669
metS
methionyl-tRNA synthetase; COG0143; expression validated by proteogenomic mapping: 11 unique peptides covering 30.3% of sequence.
  
  
 0.606
dnaN
DNA polymerase III beta chain; COG0592; expression validated by proteogenomic mapping: 18 unique peptides covering 44.2% of sequence.
  
  
 0.574
dnaE
DNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
      
 0.549
ssl2
DNA or RNA helicase of superfamily II; COG1061; expression validated by proteogenomic mapping: 21 unique peptides covering 34% of sequence.
  
    0.547
uvrB
Excinuclease ABC helicase subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits di [...]
  
  
 0.547
uvrC
Excinuclease ABC nuclease subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
     
 0.545
MMOB4610
Type III restriction-modification system methylase; COG2189; expression validated by proteogenomic mapping: 24 unique peptides covering 39.2% of sequence.
  
    0.544
Your Current Organism:
Mycoplasma mobile
NCBI taxonomy Id: 267748
Other names: M. mobile 163K, Mycoplasma mobile 163K, Mycoplasma mobile str. 163K, Mycoplasma mobile strain 163K
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