| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KGE16341.1 | KGE16913.1 | PWYN_16475 | PWYN_19755 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.568 |
| KGE16341.1 | KGE18315.1 | PWYN_16475 | PWYN_27760 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | 0.952 |
| KGE16341.1 | KGE18316.1 | PWYN_16475 | PWYN_27765 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.857 |
| KGE16341.1 | KGE18318.1 | PWYN_16475 | PWYN_27775 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.585 |
| KGE16341.1 | hemA | PWYN_16475 | PWYN_27785 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.939 |
| KGE16341.1 | hemC | PWYN_16475 | PWYN_27770 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.873 |
| KGE16341.1 | hemE | PWYN_16475 | PWYN_17100 | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.406 |
| KGE16913.1 | KGE16341.1 | PWYN_19755 | PWYN_16475 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.568 |
| KGE16913.1 | KGE18315.1 | PWYN_19755 | PWYN_27760 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | 0.902 |
| KGE16913.1 | KGE18316.1 | PWYN_19755 | PWYN_27765 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.956 |
| KGE16913.1 | KGE18318.1 | PWYN_19755 | PWYN_27775 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Siroheme synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.999 |
| KGE16913.1 | KGE20316.1 | PWYN_19755 | PWYN_13955 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | uroporphyrinogen-III synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.926 |
| KGE16913.1 | hemA | PWYN_19755 | PWYN_27785 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.734 |
| KGE16913.1 | hemC | PWYN_19755 | PWYN_27770 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
| KGE16913.1 | hemE | PWYN_19755 | PWYN_17100 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.914 |
| KGE16913.1 | hemL | PWYN_19755 | PWYN_09030 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.633 |
| KGE16913.1 | hemL-2 | PWYN_19755 | PWYN_27755 | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.668 |
| KGE18315.1 | KGE16341.1 | PWYN_27760 | PWYN_16475 | Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.952 |
| KGE18315.1 | KGE16913.1 | PWYN_27760 | PWYN_19755 | Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | uroporphyrin-III methyltransferase; Catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
| KGE18315.1 | KGE18316.1 | PWYN_27760 | PWYN_27765 | Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. | HemD protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |