STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mthfs5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (202 aa)    
Predicted Functional Partners:
GART
Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.
   
 0.971
MTHFD1
C-1-tetrahydrofolate synthase, cytoplasmic.
   
 0.936
mel-32
Serine hydroxymethyltransferase.
  
 0.931
hsdl1
Inactive hydroxysteroid dehydrogenase-like protein 1.
    
  0.747
let-767
Very-long-chain 3-oxooacyl-coA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
  0.747
hspe1
10 kDa heat shock protein, mitochondrial; Belongs to the GroES chaperonin family.
     
 0.655
Lonp1
Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. ECO:0000256|PROSITE-.
     
 0.633
Mthfr
Putative methylenetetrahydrofolate reductase.
     
 0.621
DHFR
Dihydrofolate reductase.
     
 0.566
TYMS
Thymidylate synthase.
   
  
 0.546
Your Current Organism:
Trichinella zimbabwensis
NCBI taxonomy Id: 268475
Other names: T. zimbabwensis, Trichinella zimbabwensis Pozio, Foggin, Marucci, La-Rosa, Sacchi, Corona, Rossi & Mukaratirwa, 2002
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.