node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATR | ERCC1 | A0A0V1I203 | A0A0V1HZN9 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | DNA excision repair protein ERCC-1. | 0.844 |
ATR | ERCC4 | A0A0V1I203 | A0A0V1HWT9 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | DNA repair endonuclease XPF. | 0.877 |
ATR | FANCL | A0A0V1I203 | A0A0V1I2G0 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | E3 ubiquitin-protein ligase FANCL. | 0.631 |
ATR | RPA1 | A0A0V1I203 | A0A0V1HLB0 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.989 |
ATR | TOP3A | A0A0V1I203 | A0A0V1I7N9 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.774 |
ATR | Top3b | A0A0V1I203 | A0A0V1I674 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.680 |
ATR | ercc5 | A0A0V1I203 | A0A0V1I2G4 | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | DNA repair protein-like protein. | 0.840 |
ERCC1 | ATR | A0A0V1HZN9 | A0A0V1I203 | DNA excision repair protein ERCC-1. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.844 |
ERCC1 | ERCC4 | A0A0V1HZN9 | A0A0V1HWT9 | DNA excision repair protein ERCC-1. | DNA repair endonuclease XPF. | 0.999 |
ERCC1 | FANCL | A0A0V1HZN9 | A0A0V1I2G0 | DNA excision repair protein ERCC-1. | E3 ubiquitin-protein ligase FANCL. | 0.988 |
ERCC1 | MRPL28 | A0A0V1HZN9 | A0A0V1HTS1 | DNA excision repair protein ERCC-1. | Asparagine--tRNA ligase, cytoplasmic. | 0.832 |
ERCC1 | RPA1 | A0A0V1HZN9 | A0A0V1HLB0 | DNA excision repair protein ERCC-1. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.867 |
ERCC1 | Slx4 | A0A0V1HZN9 | A0A0V1HBX5 | DNA excision repair protein ERCC-1. | Structure-specific endonuclease subunit SLX4. | 0.837 |
ERCC1 | TOP3A | A0A0V1HZN9 | A0A0V1I7N9 | DNA excision repair protein ERCC-1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.636 |
ERCC1 | Top3b | A0A0V1HZN9 | A0A0V1I674 | DNA excision repair protein ERCC-1. | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. | 0.403 |
ERCC1 | ercc5 | A0A0V1HZN9 | A0A0V1I2G4 | DNA excision repair protein ERCC-1. | DNA repair protein-like protein. | 0.887 |
ERCC1 | hay | A0A0V1HZN9 | A0A0V1HW63 | DNA excision repair protein ERCC-1. | DNA excision repair protein haywire. | 0.836 |
ERCC4 | ATR | A0A0V1HWT9 | A0A0V1I203 | DNA repair endonuclease XPF. | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. | 0.877 |
ERCC4 | ERCC1 | A0A0V1HWT9 | A0A0V1HZN9 | DNA repair endonuclease XPF. | DNA excision repair protein ERCC-1. | 0.999 |
ERCC4 | FANCL | A0A0V1HWT9 | A0A0V1I2G0 | DNA repair endonuclease XPF. | E3 ubiquitin-protein ligase FANCL. | 0.921 |