XA68_15010 protein (Ophiocordyceps unilateralis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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[Homology]

Score

XA68_15010

Peptidase_M24 domain-containing protein. (419 aa)

Predicted Functional Partners:

XA68_15257

0.997

XA68_17061

0.996

XA68_12502

0.996

XA68_13967

0.995

XA68_16212

0.992

XA68_11081

0.990

XA68_17547

0.990

XA68_15280

0.990

XA68_14230

0.988

XA68_11626

0.988

Your Current Organism:

Ophiocordyceps unilateralis

NCBI taxonomy Id: 268505
Other names: Cordyceps unilateralis, O. unilateralis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XA68_11081	XA68_11626	A0A2A9P2C2	A0A2A9PMY2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.990
XA68_11081	XA68_12502	A0A2A9P2C2	A0A2A9PCU1	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Ribosomal_L23eN domain-containing protein.	0.931
XA68_11081	XA68_13967	A0A2A9P2C2	A0A2A9PN92	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.914
XA68_11081	XA68_14230	A0A2A9P2C2	A0A2A9PA13	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	CP-type G domain-containing protein.	0.998
XA68_11081	XA68_15010	A0A2A9P2C2	A0A2A9P7S4	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Peptidase_M24 domain-containing protein.	0.990
XA68_11081	XA68_15257	A0A2A9P2C2	A0A2A9P8M5	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Ribosomal_L18_c domain-containing protein.	0.941
XA68_11081	XA68_15280	A0A2A9P2C2	A0A2A9PMG7	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein; Belongs to the universal ribosomal protein uL3 family.	0.943
XA68_11081	XA68_16212	A0A2A9P2C2	A0A2A9P6Y6	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.998
XA68_11081	XA68_17061	A0A2A9P2C2	A0A2A9P3U9	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.934
XA68_11081	XA68_17547	A0A2A9P2C2	A0A2A9PJ13	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	Uncharacterized protein.	0.990
XA68_11626	XA68_11081	A0A2A9PMY2	A0A2A9P2C2	WD_REPEATS_REGION domain-containing protein.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.990
XA68_11626	XA68_12502	A0A2A9PMY2	A0A2A9PCU1	WD_REPEATS_REGION domain-containing protein.	Ribosomal_L23eN domain-containing protein.	0.909
XA68_11626	XA68_13967	A0A2A9PMY2	A0A2A9PN92	WD_REPEATS_REGION domain-containing protein.	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.	0.649
XA68_11626	XA68_14230	A0A2A9PMY2	A0A2A9PA13	WD_REPEATS_REGION domain-containing protein.	CP-type G domain-containing protein.	0.976
XA68_11626	XA68_15010	A0A2A9PMY2	A0A2A9P7S4	WD_REPEATS_REGION domain-containing protein.	Peptidase_M24 domain-containing protein.	0.988
XA68_11626	XA68_15257	A0A2A9PMY2	A0A2A9P8M5	WD_REPEATS_REGION domain-containing protein.	Ribosomal_L18_c domain-containing protein.	0.884
XA68_11626	XA68_15280	A0A2A9PMY2	A0A2A9PMG7	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL3 family.	0.834
XA68_11626	XA68_16212	A0A2A9PMY2	A0A2A9P6Y6	WD_REPEATS_REGION domain-containing protein.	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.	0.933
XA68_11626	XA68_17061	A0A2A9PMY2	A0A2A9P3U9	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.822
XA68_11626	XA68_17547	A0A2A9PMY2	A0A2A9PJ13	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.934

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.909

expected number of edges:

11

PPI enrichment p-value:

1.42e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032511

Late endosome to vacuole transport via multivesicular body sorting pathway

6 of 47

2.45

6.34

1.24e-11

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034424

Vps55/Vps68 complex

6 of 9

3.17

9.93

6.08e-16

GO:0005770

Late endosome

5 of 66

2.22

4.67

4.19e-09

GO:0016021

Integral component of membrane

6 of 2083

0.8

0.66

0.00099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22085

Vps55/Vps68 complex, and Transmembrane amino acid transporter protein

6 of 24

2.74

7.87

1.90e-13

CL:22117

Vps55/Vps68 complex

4 of 6

3.17

5.67

2.97e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034424

Vps55/Vps68 complex

6 of 9

3.17

9.87

7.54e-16

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04133

Vacuolar protein sorting 55

2 of 2

3.35

1.85

0.0019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041260

Sld7 C-terminal domain

2 of 2

3.35

1.56

0.0051

IPR007262

Vps55/LEPROT

2 of 2

3.35

1.56

0.0051

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