XA68_13872 protein (Ophiocordyceps unilateralis)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

XA68_13872

Uncharacterized protein. (139 aa)

Predicted Functional Partners:

XA68_14215

0.997

XA68_12237

0.997

XA68_15723

0.974

XA68_13589

0.962

XA68_17064

0.952

XA68_12132

0.917

XA68_12392

0.876

XA68_12394

0.876

XA68_16228

0.865

XA68_14853

0.863

Your Current Organism:

Ophiocordyceps unilateralis

NCBI taxonomy Id: 268505
Other names: Cordyceps unilateralis, O. unilateralis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XA68_12132	XA68_12237	A0A2A9PE39	A0A2A9PDB9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.968
XA68_12132	XA68_12392	A0A2A9PE39	A0A2A9PNA8	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.768
XA68_12132	XA68_12394	A0A2A9PE39	A0A2A9PPH8	Uncharacterized protein.	RRN7-type domain-containing protein.	0.768
XA68_12132	XA68_13589	A0A2A9PE39	A0A2A9PBB9	Uncharacterized protein.	PHD-type domain-containing protein.	0.753
XA68_12132	XA68_13872	A0A2A9PE39	A0A2A9PBM3	Uncharacterized protein.	Uncharacterized protein.	0.917
XA68_12132	XA68_14215	A0A2A9PE39	A0A2A9PAV7	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.968
XA68_12132	XA68_14853	A0A2A9PE39	A0A2A9P7S6	Uncharacterized protein.	Uncharacterized protein.	0.641
XA68_12132	XA68_16228	A0A2A9PE39	A0A2A9PLP1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.915
XA68_12132	XA68_17064	A0A2A9PE39	A0A2A9P5F1	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.500
XA68_12237	XA68_12132	A0A2A9PDB9	A0A2A9PE39	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.968
XA68_12237	XA68_12392	A0A2A9PDB9	A0A2A9PNA8	WD_REPEATS_REGION domain-containing protein.	Ubiquitin-like domain-containing protein.	0.871
XA68_12237	XA68_12394	A0A2A9PDB9	A0A2A9PPH8	WD_REPEATS_REGION domain-containing protein.	RRN7-type domain-containing protein.	0.871
XA68_12237	XA68_13589	A0A2A9PDB9	A0A2A9PBB9	WD_REPEATS_REGION domain-containing protein.	PHD-type domain-containing protein.	0.993
XA68_12237	XA68_13872	A0A2A9PDB9	A0A2A9PBM3	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.997
XA68_12237	XA68_14215	A0A2A9PDB9	A0A2A9PAV7	WD_REPEATS_REGION domain-containing protein.	B30.2/SPRY domain-containing protein.	0.999
XA68_12237	XA68_14853	A0A2A9PDB9	A0A2A9P7S6	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.971
XA68_12237	XA68_15723	A0A2A9PDB9	A0A2A9PLN7	WD_REPEATS_REGION domain-containing protein.	Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.	0.997
XA68_12237	XA68_16228	A0A2A9PDB9	A0A2A9PLP1	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.953
XA68_12237	XA68_17064	A0A2A9PDB9	A0A2A9P5F1	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.996
XA68_12392	XA68_12132	A0A2A9PNA8	A0A2A9PE39	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.768

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.858

expected number of edges:

16

PPI enrichment p-value:

1.71e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051287

NAD binding

3 of 16

1.94

1.83

0.0018

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

3 of 20

1.84

1.77

0.0018

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1086

Mixed, incl. D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Aminotransferase class-V, pyridoxal-phosphate binding site

4 of 7

2.42

4.51

2.90e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00680

Methane metabolism

2 of 19

1.69

0.98

0.0355

map01120

Microbial metabolism in diverse environments

4 of 141

1.12

0.95

0.0035

map00260

Glycine, serine and threonine metabolism

2 of 27

1.53

0.87

0.0455

map00270

Cysteine and methionine metabolism

2 of 31

1.47

0.84

0.0455

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 3

2.66

3.49

1.99e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006140

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain

3 of 3

2.66

3.16

5.85e-05

IPR029753

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site

2 of 2

2.66

1.6

0.0081

IPR006139

D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain

2 of 2

2.66

1.6

0.0081

IPR036291

NAD(P)-binding domain superfamily

3 of 34

1.61

1.28

0.0081

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