XA68_12838 protein (Ophiocordyceps unilateralis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

XA68_12838

Mannosyltransferase. (523 aa)

Predicted Functional Partners:

XA68_12083

0.701

XA68_15746

0.553

XA68_17820

0.552

XA68_14116

0.541

XA68_16494

0.532

XA68_13666

0.518

XA68_16368

0.513

XA68_15727

0.509

XA68_10465

0.486

XA68_14962

0.467

Your Current Organism:

Ophiocordyceps unilateralis

NCBI taxonomy Id: 268505
Other names: Cordyceps unilateralis, O. unilateralis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XA68_10465	XA68_12838	A0A2A9P2U9	A0A2A9PDU8	PigN domain-containing protein.	Mannosyltransferase.	0.486
XA68_10465	XA68_13666	A0A2A9P2U9	A0A2A9PC62	PigN domain-containing protein.	Uncharacterized protein.	0.950
XA68_10465	XA68_14116	A0A2A9P2U9	A0A2A9PB44	PigN domain-containing protein.	Mannosyltransferase.	0.941
XA68_10465	XA68_14962	A0A2A9P2U9	A0A2A9PTU0	PigN domain-containing protein.	Uncharacterized protein.	0.659
XA68_10465	XA68_15727	A0A2A9P2U9	A0A2A9P7Z7	PigN domain-containing protein.	Uncharacterized protein.	0.518
XA68_10465	XA68_15746	A0A2A9P2U9	A0A2A9P7R6	PigN domain-containing protein.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.943
XA68_10465	XA68_16494	A0A2A9P2U9	A0A2A9P630	PigN domain-containing protein.	Uncharacterized protein.	0.463
XA68_10465	XA68_17820	A0A2A9P2U9	A0A2A9P464	PigN domain-containing protein.	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity.	0.508
XA68_12083	XA68_12838	A0A2A9PF33	A0A2A9PDU8	Uncharacterized protein.	Mannosyltransferase.	0.701
XA68_12838	XA68_10465	A0A2A9PDU8	A0A2A9P2U9	Mannosyltransferase.	PigN domain-containing protein.	0.486
XA68_12838	XA68_12083	A0A2A9PDU8	A0A2A9PF33	Mannosyltransferase.	Uncharacterized protein.	0.701
XA68_12838	XA68_13666	A0A2A9PDU8	A0A2A9PC62	Mannosyltransferase.	Uncharacterized protein.	0.518
XA68_12838	XA68_14116	A0A2A9PDU8	A0A2A9PB44	Mannosyltransferase.	Mannosyltransferase.	0.541
XA68_12838	XA68_14962	A0A2A9PDU8	A0A2A9PTU0	Mannosyltransferase.	Uncharacterized protein.	0.467
XA68_12838	XA68_15727	A0A2A9PDU8	A0A2A9P7Z7	Mannosyltransferase.	Uncharacterized protein.	0.509
XA68_12838	XA68_15746	A0A2A9PDU8	A0A2A9P7R6	Mannosyltransferase.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.553
XA68_12838	XA68_16368	A0A2A9PDU8	A0A2A9PK57	Mannosyltransferase.	Alpha-1,3-glucosyltransferase; Belongs to the ALG6/ALG8 glucosyltransferase family.	0.513
XA68_12838	XA68_16494	A0A2A9PDU8	A0A2A9P630	Mannosyltransferase.	Uncharacterized protein.	0.532
XA68_12838	XA68_17820	A0A2A9PDU8	A0A2A9P464	Mannosyltransferase.	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. Required for cell wall integrity.	0.552
XA68_13666	XA68_10465	A0A2A9PC62	A0A2A9P2U9	Uncharacterized protein.	PigN domain-containing protein.	0.950

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About