XA68_11857 protein (Ophiocordyceps unilateralis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

XA68_11857

Uncharacterized protein. (533 aa)

Predicted Functional Partners:

XA68_12624

0.992

XA68_10162

0.980

XA68_16252

0.964

XA68_13904

0.935

XA68_12762

0.935

XA68_12316

0.932

XA68_15036

0.904

XA68_15466

0.902

XA68_15325

0.898

XA68_16996

0.898

Your Current Organism:

Ophiocordyceps unilateralis

NCBI taxonomy Id: 268505
Other names: Cordyceps unilateralis, O. unilateralis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XA68_10162	XA68_11857	A0A2A9PHB5	A0A2A9PEI8	Uncharacterized protein.	Uncharacterized protein.	0.980
XA68_10162	XA68_12316	A0A2A9PHB5	A0A2A9PDG6	Uncharacterized protein.	Robl_LC7 domain-containing protein.	0.980
XA68_10162	XA68_12624	A0A2A9PHB5	A0A2A9PEC7	Uncharacterized protein.	Uncharacterized protein.	0.995
XA68_10162	XA68_12762	A0A2A9PHB5	A0A2A9PE06	Uncharacterized protein.	Uncharacterized protein.	0.969
XA68_10162	XA68_13904	A0A2A9PHB5	A0A2A9PBQ2	Uncharacterized protein.	Uncharacterized protein.	0.984
XA68_10162	XA68_15036	A0A2A9PHB5	A0A2A9P948	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.834
XA68_10162	XA68_15325	A0A2A9PHB5	A0A2A9P7E1	Uncharacterized protein.	Uncharacterized protein.	0.744
XA68_10162	XA68_15466	A0A2A9PHB5	A0A2A9PMC9	Uncharacterized protein.	Uncharacterized protein.	0.822
XA68_10162	XA68_16252	A0A2A9PHB5	A0A2A9P6T1	Uncharacterized protein.	CAP-Gly domain-containing protein.	0.976
XA68_10162	XA68_16996	A0A2A9PHB5	A0A2A9PL06	Uncharacterized protein.	Uncharacterized protein.	0.744
XA68_11857	XA68_10162	A0A2A9PEI8	A0A2A9PHB5	Uncharacterized protein.	Uncharacterized protein.	0.980
XA68_11857	XA68_12316	A0A2A9PEI8	A0A2A9PDG6	Uncharacterized protein.	Robl_LC7 domain-containing protein.	0.932
XA68_11857	XA68_12624	A0A2A9PEI8	A0A2A9PEC7	Uncharacterized protein.	Uncharacterized protein.	0.992
XA68_11857	XA68_12762	A0A2A9PEI8	A0A2A9PE06	Uncharacterized protein.	Uncharacterized protein.	0.935
XA68_11857	XA68_13904	A0A2A9PEI8	A0A2A9PBQ2	Uncharacterized protein.	Uncharacterized protein.	0.935
XA68_11857	XA68_15036	A0A2A9PEI8	A0A2A9P948	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.904
XA68_11857	XA68_15325	A0A2A9PEI8	A0A2A9P7E1	Uncharacterized protein.	Uncharacterized protein.	0.898
XA68_11857	XA68_15466	A0A2A9PEI8	A0A2A9PMC9	Uncharacterized protein.	Uncharacterized protein.	0.902
XA68_11857	XA68_16252	A0A2A9PEI8	A0A2A9P6T1	Uncharacterized protein.	CAP-Gly domain-containing protein.	0.964
XA68_11857	XA68_16996	A0A2A9PEI8	A0A2A9PL06	Uncharacterized protein.	Uncharacterized protein.	0.898

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.867

expected number of edges:

10

PPI enrichment p-value:

0.0092

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

6 of 23

2.57

5.31

4.10e-11

GO:0042180

Cellular ketone metabolic process

7 of 71

2.14

4.66

4.10e-11

GO:0044283

Small molecule biosynthetic process

9 of 458

1.44

2.47

5.09e-10

GO:0032259

Methylation

6 of 183

1.67

2.41

6.03e-07

GO:0006568

Tryptophan metabolic process

3 of 13

2.51

2.34

4.14e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004395

Hexaprenyldihydroxybenzoate methyltransferase activity

6 of 6

3.15

7.26

3.93e-14

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

5 of 5

3.15

6.0

9.23e-12

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

5 of 7

3.0

5.8

1.74e-11

GO:0004834

Tryptophan synthase activity

2 of 3

2.97

1.75

0.00068

GO:0016740

Transferase activity

7 of 1615

0.79

0.59

0.0039

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031314

Extrinsic component of mitochondrial inner membrane

5 of 22

2.51

4.31

4.12e-09

GO:0019898

Extrinsic component of membrane

6 of 97

1.94

3.39

1.38e-08

GO:0005743

Mitochondrial inner membrane

6 of 358

1.37

1.62

1.39e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15336

Ubiquinol biosynthesis, and ABC1 atypical kinase-like domain

6 of 26

2.51

5.34

2.57e-11

CL:15180

Mixed, incl. Tryptophan catabolism, and Ubiquinol biosynthesis

8 of 104

2.04

4.81

2.22e-12

CL:15339

Ubiquinone metabolic process, and ABC1 atypical kinase-like domain

5 of 20

2.55

4.44

2.60e-09

CL:15342

Ubiquinone biosynthesis, and ABC1 atypical kinase-like domain

4 of 15

2.58

3.43

3.16e-07

CL:13512

Tryptophan biosynthetic process

2 of 5

2.75

1.29

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

7 of 59

2.22

5.44

8.78e-13

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

2 of 25

2.05

1.17

0.0059

map01110

Biosynthesis of secondary metabolites

6 of 1057

0.9

0.72

0.0017

map01100

Metabolic pathways

11 of 3257

0.68

0.64

2.65e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2142789

Ubiquinol biosynthesis

8 of 22

2.71

8.54

1.10e-17

MAP-8978934

Metabolism of cofactors

8 of 40

2.45

7.31

3.54e-16

MAP-196854

Metabolism of vitamins and cofactors

8 of 220

1.71

3.41

9.71e-11

MAP-1430728

Metabolism

9 of 2234

0.75

0.65

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

7 of 971

1.01

0.85

0.0011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 140

1.7

2.14

7.82e-06

KW-0822

Tryptophan biosynthesis

2 of 3

2.97

1.77

0.00061

KW-0663

Pyridoxal phosphate

3 of 58

1.86

1.51

0.00083

KW-0831

Ubiquinone biosynthesis

2 of 9

2.5

1.5

0.0017

KW-0999

Mitochondrion inner membrane

2 of 57

1.69

0.78

0.0291

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00290

Tryptophan synthase alpha chain

2 of 2

3.15

1.31

0.0044

PF13847

Methyltransferase domain

2 of 11

2.41

0.85

0.0282

PF00291

Pyridoxal-phosphate dependent enzyme

2 of 14

2.3

0.84

0.0289

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

5 of 167

1.63

1.53

0.00032

IPR023026

Tryptophan synthase beta chain/beta chain-like

2 of 3

2.97

1.22

0.0063

IPR018204

Tryptophan synthase, alpha chain, active site

2 of 2

3.15

1.22

0.0063

IPR006654

Tryptophan synthase, beta chain

2 of 3

2.97

1.22

0.0063

IPR006653

Tryptophan synthase, beta chain, conserved site

2 of 3

2.97

1.22

0.0063

(more ...)

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