XA68_14963 protein (Ophiocordyceps unilateralis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

XA68_14963

Uncharacterized protein. (261 aa)

Predicted Functional Partners:

XA68_15329

0.999

XA68_14562

0.999

XA68_11898

0.999

XA68_15060

0.999

XA68_17330

0.998

XA68_18150

0.998

XA68_16351

0.998

XA68_15518

0.998

XA68_14995

0.998

XA68_12947

0.998

Your Current Organism:

Ophiocordyceps unilateralis

NCBI taxonomy Id: 268505
Other names: Cordyceps unilateralis, O. unilateralis

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XA68_11898	XA68_12947	A0A2A9PFV4	A0A2A9PBU4	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.999
XA68_11898	XA68_14562	A0A2A9PFV4	A0A2A9P909	Uncharacterized protein.	PINc domain-containing protein.	0.998
XA68_11898	XA68_14963	A0A2A9PFV4	A0A2A9PS51	Uncharacterized protein.	Uncharacterized protein.	0.999
XA68_11898	XA68_14995	A0A2A9PFV4	A0A2A9P859	Uncharacterized protein.	S4 RNA-binding domain-containing protein; Belongs to the universal ribosomal protein uS4 family.	0.997
XA68_11898	XA68_15060	A0A2A9PFV4	A0A2A9PL66	Uncharacterized protein.	CBF domain-containing protein.	0.999
XA68_11898	XA68_15329	A0A2A9PFV4	A0A2A9P8M4	Uncharacterized protein.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.999
XA68_11898	XA68_15518	A0A2A9PFV4	A0A2A9P7X2	Uncharacterized protein.	DRIM domain-containing protein.	0.999
XA68_11898	XA68_16351	A0A2A9PFV4	A0A2A9P6C6	Uncharacterized protein.	Sas10 domain-containing protein.	0.999
XA68_11898	XA68_17330	A0A2A9PFV4	A0A2A9P394	Uncharacterized protein.	Uncharacterized protein.	0.999
XA68_11898	XA68_18150	A0A2A9PFV4	A0A2A9P3H8	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.999
XA68_12947	XA68_11898	A0A2A9PBU4	A0A2A9PFV4	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.999
XA68_12947	XA68_14562	A0A2A9PBU4	A0A2A9P909	WD_REPEATS_REGION domain-containing protein.	PINc domain-containing protein.	0.999
XA68_12947	XA68_14963	A0A2A9PBU4	A0A2A9PS51	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.998
XA68_12947	XA68_14995	A0A2A9PBU4	A0A2A9P859	WD_REPEATS_REGION domain-containing protein.	S4 RNA-binding domain-containing protein; Belongs to the universal ribosomal protein uS4 family.	0.998
XA68_12947	XA68_15060	A0A2A9PBU4	A0A2A9PL66	WD_REPEATS_REGION domain-containing protein.	CBF domain-containing protein.	0.999
XA68_12947	XA68_15329	A0A2A9PBU4	A0A2A9P8M4	WD_REPEATS_REGION domain-containing protein.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.999
XA68_12947	XA68_15518	A0A2A9PBU4	A0A2A9P7X2	WD_REPEATS_REGION domain-containing protein.	DRIM domain-containing protein.	0.999
XA68_12947	XA68_16351	A0A2A9PBU4	A0A2A9P6C6	WD_REPEATS_REGION domain-containing protein.	Sas10 domain-containing protein.	0.999
XA68_12947	XA68_17330	A0A2A9PBU4	A0A2A9P394	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.999
XA68_12947	XA68_18150	A0A2A9PBU4	A0A2A9P3H8	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

10

PPI enrichment p-value:

0.6

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006783

Heme biosynthetic process

7 of 28

2.09

4.42

9.99e-11

GO:0006782

Protoporphyrinogen IX biosynthetic process

5 of 21

2.07

3.26

1.08e-07

GO:0019438

Aromatic compound biosynthetic process

8 of 319

1.1

1.26

2.55e-06

GO:0018130

Heterocycle biosynthetic process

8 of 362

1.04

1.14

6.20e-06

GO:1901362

Organic cyclic compound biosynthetic process

8 of 369

1.03

1.12

6.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004655

Porphobilinogen synthase activity

2 of 2

2.7

0.98

0.0165

GO:0016836

Hydro-lyase activity

3 of 49

1.48

0.65

0.0475

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 374

0.9

0.66

0.0049

GO:0005737

Cytoplasm

9 of 1536

0.46

0.32

0.0228

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6283

Porphyrin biosynthesis, and Cytochrome C assembly protein

6 of 10

2.47

5.01

1.08e-10

CL:6285

Siroheme metabolic process, and Cytochrome C assembly protein

3 of 5

2.47

2.28

5.30e-05

CL:1639

Fatty acid biosynthesis, and Acyl transferase

2 of 6

2.22

1.02

0.0125

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dti00860

Porphyrin and chlorophyll metabolism

6 of 48

1.79

2.99

3.37e-08

dti01110

Biosynthesis of secondary metabolites

7 of 347

1.0

0.99

6.41e-05

dti01120

Microbial metabolism in diverse environments

6 of 317

0.97

0.85

0.00053

dti01100

Metabolic pathways

7 of 844

0.62

0.43

0.0109

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

2 of 9

2.04

1.31

0.0030

MAP-168256

Immune System

2 of 20

1.7

1.08

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0627

Porphyrin biosynthesis

6 of 12

2.4

5.06

5.03e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030656

Delta-aminolevulinic acid dehydratase, active site

2 of 2

2.7

0.79

0.0372

IPR016036

Malonyl-CoA ACP transacylase, ACP-binding

2 of 3

2.52

0.79

0.0372

IPR014043

Acyl transferase

2 of 3

2.52

0.79

0.0372

IPR001731

Delta-aminolevulinic acid dehydratase

2 of 2

2.7

0.79

0.0372

IPR001227

Acyl transferase domain superfamily

2 of 3

2.52

0.79

0.0372

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01004

Delta-aminolevulinic acid dehydratase

2 of 2

2.7

1.39

0.0030

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