STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BQ2448_3339Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (695 aa)    
Predicted Functional Partners:
BQ2448_5893
Autophagy-related protein.
   
 0.999
BQ2448_1642
Autophagy-related protein 3.
    
 0.998
BQ2448_3582
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
    
 0.994
BQ2448_7892
BQ2448_7892 protein.
    
 0.973
BQ2448_6644
BQ2448_6644 protein.
   
 
 0.967
BQ2448_3302
Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
    
 0.920
BQ2448_4655
BQ2448_4655 protein.
   
 0.918
BQ2448_4980
BQ2448_4980 protein.
    
 0.898
BQ2448_5306
BQ2448_5306 protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.870
BQ2448_2234
BQ2448_2234 protein.
    
 0.860
Your Current Organism:
Microbotryum intermedium
NCBI taxonomy Id: 269621
Other names: HUV 3895, M. intermedium, Ustilago intermedia
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.