BQ2448_6728 protein (Microbotryum intermedium)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

BQ2448_6728

BQ2448_6728 protein. (456 aa)

Predicted Functional Partners:

BQ2448_7902

0.999

BQ2448_6021

0.998

BQ2448_2170

0.993

BQ2448_4693

0.988

BQ2448_5625

0.984

BQ2448_7684

0.982

BQ2448_3730

0.980

BQ2448_7268

0.974

BQ2448_4359

0.970

BQ2448_3068

0.969

Your Current Organism:

Microbotryum intermedium

NCBI taxonomy Id: 269621
Other names: HUV 3895, M. intermedium, Ustilago intermedia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BQ2448_2170	BQ2448_3068	A0A238F5F4	A0A238FCD1	BQ2448_2170 protein.	BQ2448_3068 protein.	0.834
BQ2448_2170	BQ2448_3730	A0A238F5F4	A0A238FIF6	BQ2448_2170 protein.	BQ2448_3730 protein.	0.998
BQ2448_2170	BQ2448_4359	A0A238F5F4	A0A238FG84	BQ2448_2170 protein.	BQ2448_4359 protein.	0.998
BQ2448_2170	BQ2448_4693	A0A238F5F4	A0A238FGS5	BQ2448_2170 protein.	BQ2448_4693 protein.	0.991
BQ2448_2170	BQ2448_5625	A0A238F5F4	A0A238F2P5	BQ2448_2170 protein.	BQ2448_5625 protein.	0.998
BQ2448_2170	BQ2448_6021	A0A238F5F4	A0A238F2Z0	BQ2448_2170 protein.	BQ2448_6021 protein.	0.988
BQ2448_2170	BQ2448_6728	A0A238F5F4	A0A238FT70	BQ2448_2170 protein.	BQ2448_6728 protein.	0.993
BQ2448_2170	BQ2448_7268	A0A238F5F4	A0A238FHR2	BQ2448_2170 protein.	BQ2448_7268 protein.	0.998
BQ2448_2170	BQ2448_7684	A0A238F5F4	A0A238FNA2	BQ2448_2170 protein.	BQ2448_7684 protein.	0.897
BQ2448_2170	BQ2448_7902	A0A238F5F4	A0A238FSD4	BQ2448_2170 protein.	Checkpoint protein; Belongs to the HUS1 family.	0.990
BQ2448_3068	BQ2448_2170	A0A238FCD1	A0A238F5F4	BQ2448_3068 protein.	BQ2448_2170 protein.	0.834
BQ2448_3068	BQ2448_3730	A0A238FCD1	A0A238FIF6	BQ2448_3068 protein.	BQ2448_3730 protein.	0.755
BQ2448_3068	BQ2448_4359	A0A238FCD1	A0A238FG84	BQ2448_3068 protein.	BQ2448_4359 protein.	0.742
BQ2448_3068	BQ2448_4693	A0A238FCD1	A0A238FGS5	BQ2448_3068 protein.	BQ2448_4693 protein.	0.987
BQ2448_3068	BQ2448_5625	A0A238FCD1	A0A238F2P5	BQ2448_3068 protein.	BQ2448_5625 protein.	0.816
BQ2448_3068	BQ2448_6021	A0A238FCD1	A0A238F2Z0	BQ2448_3068 protein.	BQ2448_6021 protein.	0.809
BQ2448_3068	BQ2448_6728	A0A238FCD1	A0A238FT70	BQ2448_3068 protein.	BQ2448_6728 protein.	0.969
BQ2448_3068	BQ2448_7268	A0A238FCD1	A0A238FHR2	BQ2448_3068 protein.	BQ2448_7268 protein.	0.747
BQ2448_3068	BQ2448_7902	A0A238FCD1	A0A238FSD4	BQ2448_3068 protein.	Checkpoint protein; Belongs to the HUS1 family.	0.822
BQ2448_3730	BQ2448_2170	A0A238FIF6	A0A238F5F4	BQ2448_3730 protein.	BQ2448_2170 protein.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

0.00172

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 221

1.47

1.6

6.34e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.04

1.32

0.0041

GO:0022900

Electron transport chain

3 of 61

1.73

0.93

0.0137

GO:0006633

Fatty acid biosynthetic process

3 of 70

1.67

0.89

0.0164

GO:0045454

Cell redox homeostasis

2 of 14

2.2

0.85

0.0272

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 4

2.74

1.06

0.0121

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 3

2.86

1.06

0.0121

GO:0000062

fatty-acyl-CoA binding

2 of 8

2.44

0.95

0.0181

GO:0016491

Oxidoreductase activity

7 of 1709

0.65

0.38

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 7

2.5

1.06

0.0115

GO:0005739

Mitochondrion

8 of 1098

0.9

0.78

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10559

Beta-ketoacyl synthase, C-terminal domain, and Lipoate metabolic process

2 of 5

2.64

0.82

0.0329

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

2 of 12

2.26

0.78

0.0365

CL:13747

Mixed, incl. Sulfide oxidation to sulfate, and Sulfate assimilation

2 of 27

1.91

0.76

0.0370

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

3 of 71

1.67

0.73

0.0365

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

3 of 137

1.38

0.69

0.0328

map00071

Fatty acid degradation

3 of 133

1.39

0.69

0.0328

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.86

1.36

0.0035

MAP-6783984

Glycine degradation

2 of 6

2.56

1.32

0.0039

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 53

1.79

1.21

0.0035

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.14

0.97

0.0152

MAP-8978868

Fatty acid metabolism

5 of 345

1.2

0.91

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005967

Mitochondrial pyruvate dehydrogenase complex

2 of 5

2.64

1.07

0.0112

GOCC:0005759

Mitochondrial matrix

4 of 165

1.43

0.88

0.0112

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.57

0.0146

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

3 of 9

2.56

2.43

2.99e-05

KW-0520

NAD

2 of 46

1.68

0.71

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 21

2.2

1.54

0.0012

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.22

0.0060

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 10

2.34

0.96

0.0175

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001753

Enoyl-CoA hydratase/isomerase

3 of 22

2.18

1.29

0.0037

IPR029045

ClpP/crotonase-like domain superfamily

3 of 34

1.99

1.15

0.0062

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

2 of 5

2.64

1.08

0.0110

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.08

0.0110

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

2 of 4

2.74

1.08

0.0110

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