node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFF98566.1 | SFG20333.1 | SAMN02982927_00280 | SAMN02982927_00949 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Homocysteine S-methyltransferase. | 0.902 |
SFF98566.1 | fhs | SAMN02982927_00280 | SAMN02982927_00289 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.890 |
SFF98566.1 | folD | SAMN02982927_00280 | SAMN02982927_00218 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.511 |
SFF98566.1 | folD-2 | SAMN02982927_00280 | SAMN02982927_03112 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.511 |
SFF98566.1 | gcvT | SAMN02982927_00280 | SAMN02982927_03090 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.867 |
SFF98566.1 | glyA | SAMN02982927_00280 | SAMN02982927_01047 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.895 |
SFF98566.1 | purH | SAMN02982927_00280 | SAMN02982927_02223 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.871 |
SFF98566.1 | purN | SAMN02982927_00280 | SAMN02982927_02220 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.870 |
SFG20333.1 | SFF98566.1 | SAMN02982927_00949 | SAMN02982927_00280 | Homocysteine S-methyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.902 |
SFG20333.1 | fhs | SAMN02982927_00949 | SAMN02982927_00289 | Homocysteine S-methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.921 |
SFG20333.1 | folD | SAMN02982927_00949 | SAMN02982927_00218 | Homocysteine S-methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.909 |
SFG20333.1 | folD-2 | SAMN02982927_00949 | SAMN02982927_03112 | Homocysteine S-methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.909 |
SFG20333.1 | gcvT | SAMN02982927_00949 | SAMN02982927_03090 | Homocysteine S-methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
SFG20333.1 | glyA | SAMN02982927_00949 | SAMN02982927_01047 | Homocysteine S-methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
SFG20333.1 | purC | SAMN02982927_00949 | SAMN02982927_02214 | Homocysteine S-methyltransferase. | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. | 0.467 |
SFG20333.1 | purF | SAMN02982927_00949 | SAMN02982927_02218 | Homocysteine S-methyltransferase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.427 |
SFG20333.1 | purH | SAMN02982927_00949 | SAMN02982927_02223 | Homocysteine S-methyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.912 |
SFG20333.1 | purN | SAMN02982927_00949 | SAMN02982927_02220 | Homocysteine S-methyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.911 |
fhs | SFF98566.1 | SAMN02982927_00289 | SAMN02982927_00280 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.890 |
fhs | SFG20333.1 | SAMN02982927_00289 | SAMN02982927_00949 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase. | 0.921 |