STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rru_A0356Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)    
Predicted Functional Partners:
Rru_A3511
Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.990
SucA
2-oxoglutarate dehydrogenase E1 component.
   
 
 0.983
Rru_A2206
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.977
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.939
Rru_A2721
2-oxoglutarate synthase, alpha subunit.
  
 
 0.938
Rru_A0019
Glutamate synthase (NADPH) large subunit.
    
 0.917
Rru_A2722
2-oxoglutarate synthase, beta subunit.
     
 0.913
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.907
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.905
Rru_A1600
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.902
Your Current Organism:
Rhodospirillum rubrum
NCBI taxonomy Id: 269796
Other names: R. rubrum ATCC 11170, Rhodospirillum rubrum ATCC 11170, Rhodospirillum rubrum S1, Rhodospirillum rubrum str. ATCC 11170, Rhodospirillum rubrum strain ATCC 11170
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