node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rru_A0141 | Rru_A1837 | Rru_A0141 | Rru_A1837 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.909 |
Rru_A0141 | Rru_A1933 | Rru_A0141 | Rru_A1933 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.899 |
Rru_A0141 | Rru_A3362 | Rru_A0141 | Rru_A3362 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.868 |
Rru_A0141 | hemA | Rru_A0141 | Rru_A0749 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.846 |
Rru_A0141 | hemC | Rru_A0141 | Rru_A3568 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.994 |
Rru_A1837 | Rru_A0141 | Rru_A1837 | Rru_A0141 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.909 |
Rru_A1837 | Rru_A1933 | Rru_A1837 | Rru_A1933 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.890 |
Rru_A1837 | Rru_A3362 | Rru_A1837 | Rru_A3362 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.862 |
Rru_A1837 | hemA | Rru_A1837 | Rru_A0749 | Porphobilinogen synthase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.844 |
Rru_A1837 | hemC | Rru_A1837 | Rru_A3568 | Porphobilinogen synthase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.994 |
Rru_A1933 | Rru_A0141 | Rru_A1933 | Rru_A0141 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.899 |
Rru_A1933 | Rru_A1837 | Rru_A1933 | Rru_A1837 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.890 |
Rru_A1933 | Rru_A3362 | Rru_A1933 | Rru_A3362 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.971 |
Rru_A1933 | gltX1 | Rru_A1933 | Rru_A0688 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA synthetase / glutamate--tRNA(Gln) ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.417 |
Rru_A1933 | gltX2 | Rru_A1933 | Rru_A1601 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.417 |
Rru_A1933 | hemA | Rru_A1933 | Rru_A0749 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.824 |
Rru_A1933 | hemC | Rru_A1933 | Rru_A3568 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.994 |
Rru_A3362 | Rru_A0141 | Rru_A3362 | Rru_A0141 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.868 |
Rru_A3362 | Rru_A1837 | Rru_A3362 | Rru_A1837 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.862 |
Rru_A3362 | Rru_A1933 | Rru_A3362 | Rru_A1933 | uroporphyrinogen-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.971 |