STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
cupinConserved hypothetical protein; Catalyzes the formation of methanethiol and 1-deoxy-D- xylulose 5-phosphate (DXP) from 1-methylthioxylulose 5-phosphate (MTXu- 5P). Involved in the MTA-isoprenoid shunt of the methionine salvage pathway. (156 aa)    
Predicted Functional Partners:
rlp
Ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Catalyzes the conversion of 5-methylthio-D-ribulose 1- phosphate (MTRu-1P) to a 3:1 mixture of 1-methylthioxylulose 5- phosphate (MTXu-5P) and 1-methylthioribulose 5-phosphate (MTRu-5P). Involved in the MTA-isoprenoid shunt of the methionine salvage pathway. Belongs to the RuBisCO large chain family. Type IV subfamily.
 
   
 0.964
Rru_A0787
Cystathionine beta-synthase.
  
   
 0.613
Rru_A0332
Glutathione S-transferase-like; Belongs to the GST superfamily.
     
 0.577
Rru_A0774
O-acetylhomoserine/O-acetylserine sulfhydrylase.
     
 0.574
mtnP
Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
      
 0.569
mtnA
Translation initiation factor 2B subunit I family (IF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Can also use deoxyribose-1-phosphate in vitro.
      
 0.568
dxs2
1-Deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
      
 0.567
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
      
 0.566
Rru_A0385
Gamma-glutamyltransferase 1. Threonine peptidase. MEROPS family T03.
      
 0.563
pepA
Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
      
 0.563
Your Current Organism:
Rhodospirillum rubrum
NCBI taxonomy Id: 269796
Other names: R. rubrum ATCC 11170, Rhodospirillum rubrum ATCC 11170, Rhodospirillum rubrum S1, Rhodospirillum rubrum str. ATCC 11170, Rhodospirillum rubrum strain ATCC 11170
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