node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rru_A0019 | Rru_A0555 | Rru_A0019 | Rru_A0555 | Glutamate synthase (NADPH) large subunit. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.703 |
Rru_A0019 | Rru_A1129 | Rru_A0019 | Rru_A1129 | Glutamate synthase (NADPH) large subunit. | Ammonium transporter. | 0.886 |
Rru_A0019 | Rru_A1130 | Rru_A0019 | Rru_A1130 | Glutamate synthase (NADPH) large subunit. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.703 |
Rru_A0019 | Rru_A1677 | Rru_A0019 | Rru_A1677 | Glutamate synthase (NADPH) large subunit. | Signal transduction histidine kinase, nitrogen specific, NtrB. | 0.545 |
Rru_A0019 | Rru_A2086 | Rru_A0019 | Rru_A2086 | Glutamate synthase (NADPH) large subunit. | L-glutamine synthetase. | 0.984 |
Rru_A0019 | glnB | Rru_A0019 | Rru_A2085 | Glutamate synthase (NADPH) large subunit. | Nitrogen regulatory protein P-II (GlnB, GlnK); P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase, so activating the enzyme; Belongs to the P(II) protein family. | 0.703 |
Rru_A0019 | glnD | Rru_A0019 | Rru_A3539 | Glutamate synthase (NADPH) large subunit. | GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.755 |
Rru_A0019 | glnE | Rru_A0019 | Rru_A2038 | Glutamate synthase (NADPH) large subunit. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.723 |
Rru_A0555 | Rru_A0019 | Rru_A0555 | Rru_A0019 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Glutamate synthase (NADPH) large subunit. | 0.703 |
Rru_A0555 | Rru_A1129 | Rru_A0555 | Rru_A1129 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Ammonium transporter. | 0.967 |
Rru_A0555 | Rru_A1677 | Rru_A0555 | Rru_A1677 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | Signal transduction histidine kinase, nitrogen specific, NtrB. | 0.783 |
Rru_A0555 | Rru_A2086 | Rru_A0555 | Rru_A2086 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | L-glutamine synthetase. | 0.565 |
Rru_A0555 | glnD | Rru_A0555 | Rru_A3539 | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.781 |
Rru_A1129 | Rru_A0019 | Rru_A1129 | Rru_A0019 | Ammonium transporter. | Glutamate synthase (NADPH) large subunit. | 0.886 |
Rru_A1129 | Rru_A0555 | Rru_A1129 | Rru_A0555 | Ammonium transporter. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.967 |
Rru_A1129 | Rru_A1130 | Rru_A1129 | Rru_A1130 | Ammonium transporter. | Nitrogen regulatory protein P-II; Belongs to the P(II) protein family. | 0.996 |
Rru_A1129 | Rru_A1677 | Rru_A1129 | Rru_A1677 | Ammonium transporter. | Signal transduction histidine kinase, nitrogen specific, NtrB. | 0.703 |
Rru_A1129 | Rru_A2086 | Rru_A1129 | Rru_A2086 | Ammonium transporter. | L-glutamine synthetase. | 0.554 |
Rru_A1129 | glnB | Rru_A1129 | Rru_A2085 | Ammonium transporter. | Nitrogen regulatory protein P-II (GlnB, GlnK); P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase, so activating the enzyme; Belongs to the P(II) protein family. | 0.997 |
Rru_A1129 | glnD | Rru_A1129 | Rru_A3539 | Ammonium transporter. | GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.799 |