node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DnaE | mutM | Rru_A1582 | Rru_A3799 | DNA polymerase III, alpha subunit. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.805 |
DnaE | polA | Rru_A1582 | Rru_A3514 | DNA polymerase III, alpha subunit. | DNA polymerase A; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.746 |
DnaE | uvrC | Rru_A1582 | Rru_A2220 | DNA polymerase III, alpha subunit. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.448 |
Rru_A3797 | Rru_A3800 | Rru_A3797 | Rru_A3800 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | Hypothetical protein. | 0.596 |
Rru_A3797 | Rru_A3801 | Rru_A3797 | Rru_A3801 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.463 |
Rru_A3797 | mutM | Rru_A3797 | Rru_A3799 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.689 |
Rru_A3797 | rpsT | Rru_A3797 | Rru_A3802 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. | 0.439 |
Rru_A3797 | ubiE | Rru_A3797 | Rru_A3798 | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.861 |
Rru_A3800 | Rru_A3797 | Rru_A3800 | Rru_A3797 | Hypothetical protein. | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.596 |
Rru_A3800 | Rru_A3801 | Rru_A3800 | Rru_A3801 | Hypothetical protein. | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.660 |
Rru_A3800 | mutM | Rru_A3800 | Rru_A3799 | Hypothetical protein. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.803 |
Rru_A3800 | rpsT | Rru_A3800 | Rru_A3802 | Hypothetical protein. | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. | 0.446 |
Rru_A3800 | ubiE | Rru_A3800 | Rru_A3798 | Hypothetical protein. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.660 |
Rru_A3801 | Rru_A3797 | Rru_A3801 | Rru_A3797 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. | 0.463 |
Rru_A3801 | Rru_A3800 | Rru_A3801 | Rru_A3800 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | Hypothetical protein. | 0.660 |
Rru_A3801 | mutM | Rru_A3801 | Rru_A3799 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.637 |
Rru_A3801 | rpsT | Rru_A3801 | Rru_A3802 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | SSU ribosomal protein S20P; Binds directly to 16S ribosomal RNA. | 0.636 |
Rru_A3801 | ubiE | Rru_A3801 | Rru_A3798 | Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase / demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.500 |
coaE | mutM | Rru_A3612 | Rru_A3799 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase / Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.827 |
coaE | nth | Rru_A3612 | Rru_A0153 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase / endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.598 |