node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAZ69203.1 | AAZ69232.1 | Mbar_A0219 | Mbar_A0248 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase. | 0.741 |
AAZ69203.1 | AAZ71120.1 | Mbar_A0219 | Mbar_A2192 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.595 |
AAZ69203.1 | AAZ71194.1 | Mbar_A0219 | Mbar_A2269 | Acetolactate synthase, small subunit. | Homocitrate synthase. | 0.595 |
AAZ69203.1 | hacB | Mbar_A0219 | Mbar_A0244 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.719 |
AAZ69203.1 | ilvC | Mbar_A0219 | Mbar_A0220 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
AAZ69203.1 | leuC | Mbar_A0219 | Mbar_A1961 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.820 |
AAZ69203.1 | leuC-2 | Mbar_A0219 | Mbar_A2167 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.820 |
AAZ69203.1 | leuD | Mbar_A0219 | Mbar_A1338 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.715 |
AAZ69203.1 | leuD-2 | Mbar_A0219 | Mbar_A2270 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.719 |
AAZ69232.1 | AAZ69203.1 | Mbar_A0248 | Mbar_A0219 | 3-isopropylmalate dehydrogenase. | Acetolactate synthase, small subunit. | 0.741 |
AAZ69232.1 | AAZ69693.1 | Mbar_A0248 | Mbar_A0715 | 3-isopropylmalate dehydrogenase. | Citrate synthase. | 0.860 |
AAZ69232.1 | AAZ71120.1 | Mbar_A0248 | Mbar_A2192 | 3-isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.971 |
AAZ69232.1 | AAZ71194.1 | Mbar_A0248 | Mbar_A2269 | 3-isopropylmalate dehydrogenase. | Homocitrate synthase. | 0.702 |
AAZ69232.1 | hacB | Mbar_A0248 | Mbar_A0244 | 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.977 |
AAZ69232.1 | ilvC | Mbar_A0248 | Mbar_A0220 | 3-isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.791 |
AAZ69232.1 | leuC | Mbar_A0248 | Mbar_A1961 | 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.987 |
AAZ69232.1 | leuC-2 | Mbar_A0248 | Mbar_A2167 | 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.934 |
AAZ69232.1 | leuD | Mbar_A0248 | Mbar_A1338 | 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.888 |
AAZ69232.1 | leuD-2 | Mbar_A0248 | Mbar_A2270 | 3-isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.976 |
AAZ69693.1 | AAZ69232.1 | Mbar_A0715 | Mbar_A0248 | Citrate synthase. | 3-isopropylmalate dehydrogenase. | 0.860 |